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Advanced Wound Repair Therapies
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Main description:

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds. Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair.
Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices. With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.


Contributor contact details Introduction Part I: Introduction to chronic wounds Chapter 1: Dysfunctional wound healing in chronic wounds Abstract: 1.1 Normal skin wound healing 1.2 Ageing skin and the onset of chronic, dysfunctional wound healing 1.3 Dysfunctional healing of chronic skin wounds 1.4 Conclusions 1.5 Acknowledgements Chapter 2: The role of micro-organisms and biofilms in dysfunctional wound healing Abstract: 2.1 Introduction 2.2 Microbiology and biofilms: not mutually exclusive 2.3 Biofilms and the interactive cooperative community 2.4 Biofilms in chronic wounds 2.5 Biofilms as therapeutic or restorative microbiology/modeling 2.6 Conclusion Chapter 3: Scarring and scarless wound healing Abstract: 3.1 Introduction 3.2 Wound healing process 3.3 Fibroproliferative scarring 3.4 Scarless fetal wound healing 3.5 Adult versus fetal wound healing 3.6 Treatment options for scars 3.7 Future trends 3.8 Conclusions Chapter 4: The discovery and development of new therapeutic treatments for the improvement of scarring Abstract: 4.1 Introduction 4.2 Scar-free and scar-forming healing 4.3 In vitro and in vivo models to investigate the mechanisms of scarring and evaluate potential treatments 4.4 Translation from pre-clinical studies to clinical efficacy 4.5 Understanding the mechanisms of action of prophylactic scar improvement therapies 4.6 Conclusions Chapter 5: Monitoring chronic wounds and determining treatment Abstract: 5.1 Introduction 5.2 Wound size measurements 5.3 Wound colour measurements 5.4 Background material Part II: Biomaterial therapies for chronic wounds Chapter 6: Functional requirements of wound repair biomaterials Abstract: 6.1 Introduction 6.2 Wound pain and dressing materials 6.3 Exudate management 6.4 Prevention and control of infection 6.5 Odour management 6.6 Future trends 6.7 Sources of further information and advice Chapter 7: Tissue-biomaterial interactions Abstract: 7.1 Introduction: definitions 7.2 Overview of tissue-biomaterial interactions 7.3 Interactions at the biomaterial surface 7.4 Tissue response to biomaterial 7.5 Conclusion Chapter 8: Polymeric materials for chronic wound and burn dressings Abstract: 8.1 Introduction 8.2 Advanced moisture-retentive wound dressings 8.3 Polymeric materials in moist wound healing dressings 8.4 Infection control by polymeric wound dressings 8.5 Conclusion 8.6 Future trends 8.7 Acknowledgements Chapter 9: Dry wound healing concept using spray-on dressings for chronic wounds Abstract: 9.1 Introduction 9.2 The key properties of an ideal wound dressing 9.3 Using protein-based spray-on dressings in practice 9.4 Case studies 9.5 Conclusions Chapter 10: Assessing the effectiveness of antimicrobial wound dressings in vitro Abstract: 10.1 Introduction 10.2 Log reduction testing 10.3 Zone of inhibition (ZOI) 10.4 Bacterial barrier testing 10.5 Other considerations 10.6 Sources of further information and advice Chapter 11: Adhesives and interfacial phenomena in wound healing Abstract: 11.1 Principles of adhesion, adhesivity and interfacial behaviour 11.2 Bioadhesion: principles of adhesion applied to wound healing 11.3 Adhesives in wound healing: materials overview 11.4 Surgical adhesives and tissue sealants: structure and properties 11.5 Conclusions Chapter 12: Wound healing studies and interfacial phenomena: use and relevance of the corneal model Abstract: 12.1 Wound dressing biomaterials: interfacial aspects of compatibility and wound response 12.2 The corneal model in wound healing and biomaterial studies 12.3 Interfacial phenomena in ocular surface contact lens studies 12.4 Wound fluid and the tear film collection 12.5 Biomaterials in mucosal wound healing 12.6 Conclusions Chapter 13: Sulphonated biomaterials as glycosaminoglycan mimics in wound healing Abstract: 13.1 Introduction 13.2 Polymers and biomimesis 13.3 Biomimetic models 13.4 Sulphonated biomaterials in the context of biomimetic principles 13.5 Sulphonated biomaterials and the chronic wound: possible modes of biomimetic behaviour 13.6 Conclusions Part III: Molecular therapies for chronic wounds Chapter 14: Drug delivery dressings Abstract: 14.1 Introduction 14.2 The role of drug delivery dressings in wound management 14.3 Topically delivered therapeutic compounds 14.4 Hydrocolloids 14.5 Hydrogels 14.6 Collagen 14.7 Alginates 14.8 Honey 14.9 Future trends Chapter 15: Molecular and gene therapies for wound repair Abstract: 15.1 Introduction 15.2 Methods of gene delivery 15.3 Gene therapy for wound healing 15.4 Ethical issues 15.5 Future trends Chapter 16: Antimicrobial dressings Abstract: 16.1 Introduction 16.2 Types of currently available dressings/formulations 16.3 Types of 'antimicrobials' 16.4 Future trends Chapter 17: Avotermin: emerging evidence of efficacy for the improvement of scarring Abstract: 17.1 There is a medical need for therapies that reduce scarring following surgery 17.2 Current treatments for scar management are unsatisfactory 17.3 New biological approaches are in development for the prophylactic improvement of scarring 17.4 Conclusions and future trends Part IV: Biologically derived and cell-based therapies for chronic wounds Chapter 18: Engineered tissues for wound repair Abstract: 18.1 Introduction 18.2 The wound microenvironment in wound repair 18.3 Traditional approaches to wound repair 18.4 Development of cellular therapies 18.5 Development of acellular therapies 18.6 Conclusion 18.7 Acknowledgement Chapter 19: Commercialization of engineered tissue products Abstract: 19.1 Introduction 19.2 Engineered templates and scaffolds 19.3 Processed tissues 19.4 Cell-based products 19.5 Lessons from the first generation 19.6 The second generation of advanced therapies 19.7 Delivering value in advanced therapies 19.8 Advanced therapies in the marketplace 19.9 Conclusion Chapter 20: Biologically derived scaffolds Abstract: 20.1 Introduction 20.2 Polyhydroxyalkanoate (PHA)-derived scaffolds 20.3 Silk-derived scaffolds 20.4 Collagen-derived scaffolds 20.5 Elastin-derived scaffolds 20.6 Resilin-derived scaffolds 20.7 Keratin-derived scaffolds 20.8 Polysaccharide-derived scaffolds 20.9 Conclusions and future trends Chapter 21: Stem cell therapies for wound repair Abstract: 21.1 Introduction 21.2 Frequently utilized sources of adult stem cells 21.3 Clinical applications of stem cells to wound healing 21.4 Conclusions 21.5 Acknowledgement 21.7 Appendix: list of abbreviations Part V: Physical stimulation therapies for chronic wounds Chapter 22: Electrical stimulation for wound healing Abstract: 22.1 Introduction 22.2 Current of injury 22.3 Physiological effects of electrical stimulation 22.4 Antibacterial effects of electrical stimulation 22.5 The effect of high voltage pulsed current (HVPC) on wound healing 22.6 The effect of low intensity direct currents (LIDC) on wound healing 22.7 Other types of electrical stimulation applied to wounds 22.8 Discussion 22.9 Conclusion Chapter 23: Negative pressure wound therapy Abstract: 23.1 Introduction 23.2 History of negative pressure wound therapy 23.3 The science of negative pressure 23.4 The pathophysiologic mechanisms of action of negative pressure 23.5 The search for the perfect negative pressure technology 23.6 Conclusions 23.7 Acknowledgement Chapter 24: Debridement methods of non-viable tissue in wounds Abstract: 24.1 Introduction 24.2 Background 24.3 Complications of non-viable tissue in wounds and the need for debridement 24.4 Presence of biofilm 24.5 Organisation of debridement 24.6 Timing and types of debridement 24.7 Scoring the effectiveness of debridement 24.8 Debridement in the diabetic foot 24.9 Conclusions Index


ISBN-13: 9780081016992
Publisher: Woodhead Publishing Ltd
Publication date: October, 2017
Pages: 672
Weight: 571g
Availability: Contact supplier
Subcategories: Accident & Emergency Medicine, Biomedical Engineering, General Issues


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