Main description:

Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Contents:

Part I Acute Myeloid Leukemia.- Acute Myeloid Leukemia: Epidemiology and Etiology.- Clinical Presentation, Diagnosis and Classification of Acute Myedloid Leukemia.- Selection of Patients for Therapy.- Therapy of Newly Diagnosed AML.- Management of Relapsed and Refractory AML.- Stem cell Transplant in AML.- Investigational Therapies in AML.- Acute Lymphoblastic Leukemia.- Acute Lymphoblastic Leukemia: Epidemiology abnd Etiology.- Molecular Biology and Genetics.- Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification.- Therapy of Newly Diagnosed Adult ALL.- Approach to Newly Diagnosed Pediatric and AYA ALL.- The Role of Immunotherapy in ALL.- STem Cell Transplantation in the Treatment of ALL.- The Significance of Minimal Residual Disease in Acute Lymphoblastic Leukemia.- Philadelphia Chromosome - Positive Acute Lymphoblastic Leukemia.- BCR-ABL-like ALL: Diagnosis and Management.- Burkitt's Acute Lymphoblastic Leukema in Adults.- Treatment of Lymphoblastic Lymphoma in Adults.- Central Nervous System Involovment in Adult Acute Lymphocytic Leukemia.- Management of Relapsed and Refractory ALL.- Emergencies in Acute Lymphoblastic Leukema.- Investigational Therapies in ALL