Main description:

This book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms-magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria-that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles.

Contents:

1. Micro- and Nano-Technologies to Probe Brain Mechanobiology2. Acute Neural Stimulation3. Chronic Neural Stimulation4. Phenotypic Selection of Magnetospirillum magneticum (AMB-1) Over-Producers using Magnetic Ratcheting5. Magnetic Microfluidic Separation for Estimating the Magnetic Contents of Magnetotactic Bacteria6. Outlook for Magnetic Neural Stimulation TechniquesAppendix