Main description:

Important aspects of modern organic synthesis such as atom economy, organo- and supramolecular catalysis, metal-mediated reactions, mechanisms and processes selectivity, green chemistry approaches and microwave assistance are discussed in the context of multicomponent assembling of heterocycles from activated alkynes. Applications in medicinal chemistry and material sciences for heterocyclic products achieved using cascade reactions above will be demonstrated. The book will be of interest to specialists and grad students in organic and element organic chemistry, coordination and biological chemistry and will stimulate discussions and further investigations in this area of chemistry.

Contents:

Introduction. Metal-Catalyzed Multicomponent Synthesis of Heterocycles from Activated Alkynes. Multicomponent Reactions of Activated Alkynes with Isonitriles. Highly Efficient Reactivity of Activated Alkynes in Multicomponent Synthesis of N-containing Heterocycles. Synthesis of Heterocycles via Multicomponent Reactions of Activated Acetylenes with C-,O-, S-, P-Nucleophiles. Activated Alkynes in Organocatalyzed Multicomponent Assembly of Polyfunctional Heterocycles. Multicomponent Synthesis of Spirocyclic Heterocycles from Activated Acetylenes. Metal-free Multicomponent Conversion of Si/Ge Alkynyl Carbonyl Compounds into Functionalized Heterocycles. Multicomponent Synthesis of Heterocycles via 1,3-Dipolar Cycloaddition to Electron-deficient Alkynes. Microwave-Assisted Multicomponent Reactions involving Activated Acetylenes and Nucleophiles for the Synthesis of Heterocycles. Application of multifunctional heterocycles in medicine chemistry and material science.