Main description:

Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. The assessment and management of refractory patients with mood disorders is a major clinical challenge for mental health providers. Part of the Oxford Psychiatry Library (OPL) series, this pocketbook provides a concise view of the current definitions, assessment and evidence-based management of
treatment-resistant mood disorders and reviews novel therapeutic targets for mood disorders, which may enhance the therapeutic armamentarium of clinicians in the near future. The pocketbook serves as a useful guide for mental health practitioners, including psychiatrists, clinical psychologists, trainees, and
interested primary care physicians.

Contents:

1. Treatment-resistant major depressive disorder: Current Definitions, Epidemiology and Assessment ; 2. Treatment-resistant bipolar disorder: current definitions, epidemiology and assessment ; 3. Determinants of Treatment Resistance: Health Systems and Public Policy Implications ; 4. The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders ; 5. Predictors of treatment response in major depressive disorder ; 6. Predictors of Treatment Response in Bipolar Disorder: Lessons from Longitudinal Studies ; 7. Evidence-based Pharmacological Approaches for Treatment-Resistant Major Depressive Disorder ; 8. Evidence-based pharmacological approaches for treatment-resistant bipolar disorder ; 9. Psychosocial management of treatment-resistant mood disorders: current evidence ; 10. Electroconvulsive therapy for treatment-resistant mood disorders ; 11. Novel non-invasive brain stimulation approaches for treatment-resistant mood disorders ; 12. Vagus Nerve Stimulation and Deep Brain Stimulation: Implantable Device-Related Neurostimulation for Treatment-Resistant Mood Disorders ; 13. Novel Therapeutic Targets for Major Depressive Disorder ; 14. Novel therapeutic targets for bipolar disorder