Main description:

Leading and emerging investigators from within and outside the immediate area of cerebrovascular disease have come together to explore the state-of-the-art and future directions of research and clinical practice leading to enhanced medical care in the acute treatment of ischemic stroke. The agenda highlights various facets of acute intervention and a number of unaddressed issues related to the medical setting of stroke that impact clinical outcomes and provide opportunities for improving treatment. The main goals are the generation of data-driven, multidisciplinary ideas, to explore ischemic stroke as a systemic disease related to other disease entities (hypertension, diabetes, and disorders of aging), and to better address the evolution of ischemic brain injury. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org).
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Contents:

Introduction to Thrombolysis and Acute Stroke Treatment: Preparing for the Next Decade vii Gregory J. del Zoppo and Andrei V. Alexandrov Advanced multimodal CT/MRI approaches to hyperacute stroke diagnosis, treatment and monitoring 1 David S. Liebeskind and Andrei V. Alexandrov The future of stroke thrombolysis 8 Antoine M. Hakim Population shifts and the future of stroke: forecasts of the future burden of stroke 14 George Howard and David C. Goff Pathobiology of injury after stroke: the neurovascular unit and beyond 21 Ulrich Dirnagl The ischemic penumbra: how does tissue injury evolve? 26 Wolf-Dieter Heiss Current treatment of basilar artery occlusion 35 Perttu J. Lindsberg, Tiina Sairanen, Daniel Strbian, and Markku Kaste Improving public education about stroke 45 Mark J. Alberts Impact of regional pre-hospital emergency medical services in treatment of patients with acute ischemic stroke 51 Cemal B. Sozener and William G. Barsan Techniques for improving efficiency in the emergency department for patients with acute ischemic stroke 57 Edward C. Jauch, Christine Holmstedt, and Justin Nolte Imaging-based selection in acute ischemic stroke trials- a quest for imaging sweet spots 63 Andrew M. Demchuk, Bijoy Menon, and Mayank Goyal Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial 72 Andrew M. Southerland and Karen C. Johnson Treatment of acute ischemic stroke: systemic or local? 79 Rudiger von Kummer and Johannes Gerber How baseline severity affects efficacy and safety outcomes in acute ischemic stroke intervention trials 85 Philip B. Gorelick Does inhibiting Sur1 complement rt-PA in cerebral ischemia? 95 J. Marc Simard, Zhihua Geng, Frank L. Silver, Kevin N. Sheth, W. Taylor Kimberly, Barney J. Stern, Mario Colucci, and Volodymyr Gerzanich Safety and efficacy of 0.6 mg/kg rt-PA: optimum rt-PA dose revisited 108 Etsuro Mori Ancillary approaches to plasminogen activators 113 Reza Bavarsad Shahripour and Andrei V. Alexandrov Selection of possible responders to thrombolytic therapy in acute ischemic stroke 120 Christian Hametner, Peter Arthur Ringleb, Werner Hacke, and Lars Kellert Aging and the neurovascular unit 127 Gregory J. del Zoppo Intra-arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate 134 Ziad M.K. El-Zammar, Julius Gene S. Latorre, Dongliang Wang, Shyama Satyan, Elwaleed Elnour, Adham Kamel, Ashok Devasenapathy, and Yahia M. Lodi Timing of thrombolysis for acute ischemic stroke: timing is everything or everyone is different 141 James Grotta Pre- and in-hospital intersection of stroke care 145 Atte Meretoja and Markku Kaste A strategic plan to accelerate development of acute stroke treatments 152 John R. Marler Corrigendum for Ann. N.Y. Acad. Sci. 2010. 1195. 1-27 157