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MORE ABOUT THIS BOOK
Main description:
In recent years, there has been great interest in exploiting thehypoxic tumour microenvironment for therapeutic gain. It has alsobecome clear that this microenvironment is acidic and thus hostileto the growth and survival of viable normal cells. Theseobservations lead to several fundamentally important questions thatform the basis for this book. What are the relationships betweentumour perfusion and tumour pH? What are the effects of tumour pHand hypoxia on carcinogenesis or tumorigenesis? What are thetherapeutic consequences of tumour pH?
This exciting book brings together leading clinicians andresearchers to address some of these key issues. It is hypothesizedthat low extracellular pH is not only an important consequence oftumour growth but may also promote further tumorigenictransformation. Furthermore, in vitro studies suggest that low pHstrongly affects the efficacy of chemo– and radiotherapy.Therapeutic strategies taking into account the consequences ofaltered pH, or which seek to manipulate tumour pH, more be moreeffective than those currently employed.
Back cover:
In recent years, there has been great interest in exploiting thehypoxic tumour microenvironment for therapeutic gain. It has alsobecome clear that this microenvironment is acidic and thus hostileto the growth and survival of viable normal cells. Theseobservations lead to several fundamentally important questions thatform the basis for this book. What are the relationships betweentumour perfusion and tumour pH? What are the effects of tumour pHand hypoxia on carcinogenesis or tumorigenesis? What are thetherapeutic consequences of tumour pH?
This exciting book brings together leading clinicians andresearchers to address some of these key issues. It is hypothesizedthat low extracellular pH is not only an important consequence oftumour growth but may also promote further tumorigenictransformation. Furthermore, in vitro studies suggest that low pHstrongly affects the efficacy of chemo– and radiotherapy.Therapeutic strategies taking into account the consequences ofaltered pH, or which seek to manipulate tumour pH, more be moreeffective than those currently employed.
Contents:
Introduction (Robert J Gillies).
Frontiers in the Measurement of Cell and Tissue pH (Robert JGillies and Ronald M Lynch).
The Physiological Environment in Cancer Vascularization, Invasionand Metastasis (Zaver M Bhujwalla et al).
Why are Cancers Acidic? A Carrier–Mediated Diffusion Model for H+Transport in the Interstitial Fluid (J R Griffiths et al).
pH and Therapy of Human Cancers (Jeffrey L Evelhoch).
Mathematical Models of Tumour Invasion Mediated byTransformation–Induced Alteration of Microenvironmental pH (RobertA Gatenby and Edward T Gawlinski).
pH Regulation of Renal Gene Expression (Norman P Curthoys etal)).
Genetic Determinants that influence Hypoxia–Induced Apoptosis(Rodolfo M Alarcon et al).
Genomic Instability in Cancer (Sara Rockwell et al).
pH, Hypoxia and Metastasis (R P Hill et al).
Modelling Tumour Acidity and Invasion (Steven D Webb et al).
pH, Aerobic Glycolysis and Vascular Endothelial Growth Factor inTumour Growth (Jacques Pouysse gur et al).
pH and Chemotherapy (Natarajan Raghunand).
The HIF Pathway: Implications for Patterns of Gene Expression inCancer (Charles C Wykoff et al).
pH and Multidrug Resistance (Paul D Roepe).
′The Metabolism of Tumours′ 70 Years Later (Gregg L Semenza etal).
The Multiple Mechanisms of Multidrug Resistance and Cellular pH(Sanford Simon).
Summing Up (Robert J Gillies).
Index of Contributors.
Subject Index.
PRODUCT DETAILS
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: October, 2008
Pages: 314
Dimensions: 157.00 x 235.00 x 19.00
Weight: 610g
Availability: Not available (reason unspecified)
Subcategories: Diseases and Disorders
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CUSTOMER REVIEWS
I read this book from A to Z and I really enjoyed it...makes youwish you had been there, but if you were not, you can always buythis book..." (NMR in Biomedicine, October 2002)
"...an excellent compilation of some specific and significantwork..." (Pharmaceutical Research, Vol. 19, No. 10, October2002)