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MORE ABOUT THIS BOOK
Main description:
This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included.
Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.
Contents:
Foreword
Preface
Chapter 1
Resistance to Targeted Therapies As a Result of Mutation(s) in the Target
Alexis B. Cortot and Pasi A. Janne
Chapter 2
The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies
Daniel G. Gioeli
Chapter 3
Cancer Signaling Network Analysis by Quantitative Mass Spectrometry
Jason R. Neil and Forest M. White
Chapter 4
Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications
Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta, and Emanuel F. Petricoin III
Chapter 5
Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies
Omar D. Perez
Chapter 6
Mathematical and Computational Models in Cancer
Sudhir Chowbina, Kevin Janes, Shayn M. Peirce, and Jason Papin
Chapter 7
Somatic Evolution of Acquired Drug Resistance in Cancer
John W. Pepper
Chapter 8
Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer
Edward Gunther
Chapter 9
MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways
Benjamin Kefas and Benjamin W. Purow
Chapter 10
Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance
Yun Dai and Steven Grant
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: June, 2011
Pages: 215
Weight: 494g
Availability: Available
Subcategories: General Issues, Oncology
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