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Main description:
This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment.
The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Contents:
Preface
Nathan A. Berger
Contributors
Chapter 1: Relevance of Circadian Rhythm in Cancer
Luciano DiTacchio, Kacee A. DiTacchio, and Satchidananda Panda
Chapter 2: Environmental Manipulation and Neuropeptide Effects on Energy Balance and Cancer
Lei Cao
Chapter 3: The MRL Mouse: A Model of Regeneration and Cancer
Ellen Herber-Katz and Robert K. Naviaux
Chapter 4: Living Large: What Mouse Models Reveal about Growth Hormone and Obesity
Darlene E. Berryman, Lara Householder, Vivian Lesende, Edward O. List, John J. Kopchick
Chapter 5: Mouse Models to Study Obesity Effects on Hematologic Malignancies
Jonathan Tucci and Steven D. Mittelman
Chapter 6: Energy Balance, IGF-1 and Cancer: Causal Lessons from Genetically Engineered Mice
Stephen D. Hursting, Emily L. Rossi, Laura W. Bowers, and Laura M. Lashinger
Chapter 7: Mouse Models to Study Leptin in Breast Cancer Stem Cells
Praveena S. Thiagarajan and Ofer Reizes
Chapter 8: Mouse Models used to study the effects of Diabetes, Insulin and IGFs on cancer
Zara Zelenko, Derek LeRoith, Emily J. Gallagher
Chapter 9: Impact of Energy Balance on Chemically Induced Mammary Carcinogenesis in the Rat
Henry J. Thompson
Chapter 10: Models and Mechanisms of High Fat Diet Promotion of Pancreatic Cancer
Hui-Hua Chang, Guido Eibl, and Enrique Rozengurt
Chapter 11: Maternal energetics and the developmental origins of prostate cancer in offspring
Emily C. Benesh and Kelle H. Moley
Chapter 12: Mouse Models to Study the Effect of Natural Products on Obesity Associated NAFLD/NASH
Dipali Sharma and Neeraj K. Saxena
Chapter 13: Mouse Models to Study Metformin Effects in Carcinogenesis
Abraham Schneider
Subject Index
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: July, 2015
Pages: 269
Weight: 5915g
Availability: Available
Subcategories: General Issues, Oncology
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