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High-Grade Gliomas
Diagnosis and Treatment
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Main description:

This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such "breakthrough" in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).


Contents:

Classification of High-Grade Glioma

Histologic Classifications

Richard Prayson

Molecular Classifications

Greg Fuller

Clinical Characteristics

Pediatric High-Grade Glioma

Bruce Cohen

Adult High-Grade Glioma

Susan Chang and Nicholas Butowski

Diagnostic Tools for High-Grade Glioma

Computerized Tomography

Thomas Masaryk and Manzoor Ahmed

Magnetic Resonance Imaging

Paul Ruggieri

Magnetic Resonance Spectroscopy

Mitchell Berger, G. Evren Keles, and Soonmee Sha

Biological Imaging

Tim Roberts and Andrea Kassner

Nuclear Imaging

Alexander M Spence, David Mankoff, Mark Muzc, and Kristin Swanson

Magneto-Encephalography

Michael Steinmetz, Jurgen Luders, and Edward Benzel

Management

General Considerations

Glen Stevens

Surgical Techniques

Gene Barnett

Radiation Therapy

Minesh Mehta and Hiral Shah

Brachytherapy

Michael McDermott, Marcus Ware, and P.K. Sneed

Radiosurgery

John Suh and Gene Barnett

Chemotherapies

David Peereboom and Manmeet Singh Ahluwalia

Nursing Considerations

Kathy Lupica and Gail Ditz

Contemporary Investigational Treatments

Convection Enhanced Delivery

Andrew Kanner

Immunotoxins

Syed Husain and Raj Puri

Small Molecule Agents

Michael Vogelbaum and Tina Thomas

Immunotherapy

Roberta Glick, Terry Lichter, Henry Lin, and Edward Cohen

Monoclonal Antibodies

Abraham Boskovitz David Reardon, Carol Wikstrand, Michael Zalutsky, and Darell Bigner

Oncolytic Viral Therapies

Antonio Chiocca and M.L. Lamfers

Biologic Modifiers

Aleck Hercbergs, Alex Mason, and Steve Toms

Gene Therapy

Alessandro Olivi and Maciej Lesniak

Boron Neutron Capture Therapy of Brain Tumors: Current Status and Future Prospects

Rolf Barth, Jeffrey Coderre, Graca Vicente, Thomas Blue, and Shin-Ichi Miyatake

Photodynamic Therapy

Andrew Kaye and Bhadrakant Kavar


PRODUCT DETAILS

ISBN-13: 9781588295118
Publisher: Springer (Humana Press Inc.)
Publication date: September, 2006
Pages: 508
Weight: 1115g
Availability: Available
Subcategories: Neurosurgery, Oncology
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