Main description:

This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, novel biomarkers, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments for possible functional cure of HBV infection.

In this second edition, authors provides recent updates in epidemiology, biomarkers, antivirus therapy, and novel therapy for functional cure of chronic hepatitis B virus infection.

The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection.

Contents:

1 Molecular Virology and Life Cycle of Hepatitis B Virus 2 Unmet Needs in Basic Research of Hepatitis B Virus Infection: In Vitro and In Vivo Models 3 Unmet Needs Clinical Research Hepatitis B 4 Immunopathogenesis of Hepatitis B Virus Infection 5 Pathology of Hepatitis B Virus (HBV) Infection and HBV-related Hepatocellular Carcinoma 6 Molecular Carcinogenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma 7 Epidemiology and Natural History of Hepatitis B Virus Infection 8 Hepatitis B Vaccines 9 Viral and Host Factors Affecting Disease Progression of Hepatitis B Virus Infection 10 Novel Biomarkers for the Management of Chronic Hepatitis B Virus Infection 11 Chronic hepatitis B virus infection: Non-invasive assessment of liver disease 12 Chronic Hepatitis B Virus Infection: Interferon Therapy and Long-Term Outcomes 13 Nucleos(t)ide therapy and long-term outcomes 14 Combination therapy 15 Treatment of HCV, HDV or HIV Coinfections 16 Management of Chronic Hepatitis B Virus Infection in Children and Pregnant Women 17 Occult Hepatitis B Infection 18 Hepatitis B Virus Reactivation and Management of Patients undergoing Immunosuppression 19 Novel Therapy for Functional Cure of Chronic Hepatitis B Virus Infection 20 Is Cure of Hepatitis B infection a mission possible?