Main description:

Cannabis Use, Neurobiology, Psychology, and Treatment offers readers a comprehensive reference on neurological changes, both transient and long-term, and other factors surrounding the use of these compounds and extracts. With coverage of both natural and synthetic cannabinoids, this broad coverage allows readers to learn about both adverse and non-adverse effects, including reactivity to pain, changes in behavior, and neuroactivity. This volume provides a platform for research on the effects of these compounds in brain function and neurological dysfunction. Extracts from the Cannabis sativa plant contain scores of psychoactive compounds in addition to the principal agent tetrahydrocannabinol, many of which are neuroactive.

Contents:

I. Setting the scene and introductory chapters 1. Metabolomics of the cannabis plant 2. The roots of Cannabis sativa: chemical and pharmacological profile 3. Cannabis related compounds in beverages and food 4. The impact of prenatal cannabis exposure: an overview 5. Cannabinoid Genotoxicity and Congenital Anomalies: A Convergent Synthesis of European and USA Datasets 6. Cannabis Genotoxicity and Cancer Incidence: A Highly Concordant Synthesis of European and USA Datasets 7. Cannabis, Cognitive impairment and Car Crash risk

II. Cannabis usage 8. Recreational cannabis use: a French perspective of adverse effects 9. Acute and chronic impact of cannabis on human cognition 10. Polydrug users, use of cannabidiol (CBD) and abuse potential/Polydrug users, use of cannabinoids and abuse potential 11. Cannabis stigmas: a narrative of features 12. Alterations of THC and CBD ratios and impact on cognition 13. When cannabis is used for medicinal purposes: a focus on back pain

III. Pharmacological and Physiological Aspects 14. Cannabis, cannabinoids and receptor responses 15. Cannabidiol (CBD): abuse potential and withdrawal 16. 4,5- Dihydro-1H-pyrazole/3,4-Diarylpyrazoline class of cannabinoid-1 (CB1R) receptor antagonists and their potential in medicinal applications

IV. Neurobiology of cannabis 17. Neurobiology of cannabis 18. The kynurenine pathway, neurobiology and cannabis misuse: a new narrative 19. Central nervous system cancers and use of cannabis and related products: an updated narrative 20. Chronic cannabis users: links with glutamate and resting state connectivity 21. Brain metabolic responses to cannabis use in people with multiple sclerosis: Insights from [18F]-FDG positron emission tomography and functional MRI 22. Genetic Variation and Acute Responses to Cannabis 23. Cell Signaling of the CB1 Cannabinoid Receptor via beta-arrestins, Cannabinoid Receptor Interacting Protein (CRIP1a) and other regulatory proteins 24. Cannabis and impact on memory: from in utero to adults 25. Central CB1 receptors and age-related changes: investigating the effects of DELTA-9-tetrahydrocannabinol 26. Alcohol, cannabis and visual memory

V. Neurobiology of cannabinoids 27. The role of Delta-FosB in the plasticity of the cannabinoid system 28. Functional profile of synthetic cannabinoid receptor agonists: exploring cannabinoid and non-cannabinoid targets 29. Linking the G protein-coupled orphan receptor GPR55 to the cannabinoid receptors (CB1 and CB2): a new narrative 30. Proteomic analysis of cannabinoids in human oligodendrocytes 31. Cannabinoids and endocannabinoid signaling at the basal forebrain cholinergic system 32. Cannabidiol (The major non-psychotropic cannabinoid in the cannabis plant) and the PI3K/Akt pathway in the CNS 33. Effects of cannabidiol and other phytocannabinoids on ion channels 34. Cannabis, neurodevelopment and the "two-hit hypothesis"

VI. New and synthetic cannabinoids 35. Impact of tetrahydrocannabinol (THC ) and synthetic "spice"cannabinoids on nicotine use and abuse 36. Synthetic cannabinoids: how do they compare to DELTA9-tetrahydrocannabinol: neurological effects and beyond

VII. Biomarkers, analysis and screening 37. The DSM-5 criteria of cannabis use disorder: methods and applications 38. Cannabis and clinical high risk for psychosis: monitoring and smartphones

VIII. Impact on non-neurological systems 39. The impact of cannabis and cannabinoids on the skin 40. Cannabis consumption in reproduction and teratogenicity 41. Cannabis compounds and putative cytotoxicity: profile of cancer cells

IX. Treatments, strategies and resources 42. Motivational Interviewing for Cannabis Use Disorders: a narrative review from research to practice 43. An Overview of Current Pharmacologic Interventions for Management of Cannabis Withdrawal and the Evidence for Their Use 44. Managing cannabinoid hyperemesis syndrome in paediatrics: A new narrative review 45. Gabapentinoids for the Treatment of Cannabis Use Disorder: A Focus on Human Laboratory Research 46. Treating psychosis in users of synthetic cannabinoids

X. Resources 47. Cannabis and Web based Resources