Main description:

This volume explores the latest techniques used to study brain function and pathophysiology of major depressive disorder (MDD), and includes suggestions of new therapeutic approaches for the treatment of MDD. The chapters into this book are organized into five parts. Part One discusses advanced approaches to studying well-established pathophysiological mechanisms. Part Two details behavioral research methods for MDD. Part Three looks at the cellular and molecular research methods for major depression, and Part Four describes the latest developments in non-invasive neuroimaging. Part Five focuses on the pharmacological and non-pharmacological interactions, including antidepressant agents and their properties, such as sexual side effects and neuroimaging biomarkers. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, Translational Research Methods for Major Depressive Disorders is a valuable resource for researchers and scientists interested in learning more about this important and developing field.

Contents:

Series Preface...
Preface...
Table of Contents...
Contributing Authors...

Part I Translational Research Approach and Current Hypotheses of Major Depressive Disorder

1. The Role of Hypothalamus-Pituitary-Adrenal Axis in the Pathophysiology of Major Depression: A Translational Research Perspective of the Prednisolone Suppression Test
Mario F. Juruena, Allan H. Young, and Anthony J. Cleare

2. The Role of Glial Pathology in Pathophysiology and Treatment of Major Depression: Clinical and Preclinical Evidence
Alper Evrensel and Nevzat Tarhan

3. Neural Circuits Underlying the Pathophysiology of Major Depression
Meysam Amidfar and Yong-Ku Kim

4. Translational Research Approach to Neurobiology and Treatment of Major Depression: From Animal Models to Clinical Treatment
Michel Bourin

Part II Behavioral Research Methods for Major Depression

5. Translational Strategies for Developing Biomarkers for Major Depression: Lessons Learned from Animal Models
Feyza Aricioglu and Brian E. Leonard

6. Animal Model Approaches to Understanding the Neurobiology of Suicidal Behavior
Raquel Romay-Tallon and Graziano Pinna

7. Behavioral Paradigms for Assessing Cognitive Functions in the Chronic Social Defeat Stress Model of Depression
Marc Fakhoury, Michael Fritz, and Sama F. Sleiman

Part III Cellular and Molecular Research Methods for Major Depression

8. Optogenetic Animal Models of Depression: From Mouse to Man
Ayla Arslan, Pinar Unal-Aydin, Taner Dogan, and Orkun Aydin

9. The Effects of Antidepressants on Neurotransmission: Translational Insights from In Vivo Electrophysiological Studies
Meysam Amidfar and Yong-Ku Kim

10. The Role of Transcriptional Profiling in Neurobiology and Treatment of Major Depression: A Translational Perspective on RNA-Sequencing Platform
Bhaskar Roy, Praveen Korla, and Yogesh Dwivedi

Part IV Neuroimaging Research Methods for Major Depression

11. Molecular Imaging of Major Depressive Disorder with Positron Emission Tomography: Translational Implications for Neurobiology and Treatment
Mikael Tiger and Johan Lundberg

12. Magnetic Resonance Imaging as a Translational Research Tool for Major Depression
Chien-Han Lai

13. Neurobiochemistry Alterations Associated with Major Depression: A Review of Translational Magnetic Resonance Spectroscopic Studies
Darren William Roddy, John R. Kelly, Thomas Drago, Kesidha Raajakesary, Madeline Haines, and Erik O'Hanlon

14. Deficits of Neurotransmitter Systems and Altered Brain Connectivity in Major Depression: A Translational Neuroscience Perspective
Je-Yeon Yun and Yong-Ku Kim

Part V Translational Interventions

15. Translational Neuropsychopharmacology for Major Depression: Targeting Neurotransmitter Systems
Hyewon Kim, Yong-Ku Kim, and Hong Jin Jeon

16. Transcranial Direct Current Stimulation for the Treatment of Major Depressive Disorder
Lucas Borrione, Lais B. Razza, Adriano H. Moffa, and Andre R. Brunoni

17. Deep Brain Stimulation for Treatment-Resistant Depression
Alexandre Paim Diaz, Brisa S. Fernandes, Valeria A. Cuellar, Joao Quevedo, Albert J. Fenoy, Marsal Sanches, and Jair C. Soares

18. Serotonin Receptors and Antidepressants: Neuroimaging Findings from Preclinical and Clinical Research
Patricia A. Handschuh, Melisande E. Konadu, Benjamin Spurny-Dworak, Leo R. Silberbauer, Matej Murgas, and Rupert Lanzenberger

19. Ketamine and Other Glutamate Receptor Antagonists as Fast-Acting Antidepressants: Evidence from Translational Research
Mu-Hong Chen, Tung-Ping Su, and Shih-Jen Tsai

20. Antidepressants, Sexual Behavior, and Translational Models for Male Sexual Dysfunction: Development of Animal Models, Pharmacology, and Genetics
Jocelien D.A. Olivier, Josien Janssen, Tommy Pattij, Stephen De Pretre, and Berend Olivier

Subject Index List...