Main description:

According to the World Health Organization, antimicrobial resistance is a major threat to global health because the number of alternative antibiotics is very limited. Antimicrobial resistance is a slow evolutionary process that has been accelerated by human activities in health, environment and agriculture sectors. Due to their wide application, antibiotics and their residues have been found in almost all food products and natural ecosystems. This book reviews the drivers, impact and mitigation of antimicrobial resistance, with focus on methods and targets.

Contents:

Preface

Chapter 1 - Antimicrobial resistance paradigm and One-health approach

Kumar Siddharth Singh, Santosh Anand, Sunny Dholpuria, Jitendra Kumar Sharma, Yogesh Shouche

Chapter 2 - Global surveillance programs on antimicrobial resistance

Sunil Kumar, Mayank Chaudhary, Mukesh Yadav, Vikas Kumar

Chapter 3 - Antimicrobial resistance, food systems and climate change

Mashkoor Mohsin, Ahtesham Ahmad Shad, Jabir Ali, Sajjad-ur-Rahman

Chapter 4 - In silico approaches for prioritizing drug targets in pathogens

Mariana Santana, Stephane Fraga de Oliveira Tosta, Arun Kumar Jaiswal, Leticia de Castro Oliveira, Siomar C. Soares, Anderson Miyoshi, Luiz Carlos Junior Alcantara, Vasco Azevedo, Sandeep Tiwari

Chapter 5 - Molecular and systems biology approaches for analyzing drug-tolerant bacterial persister cells

Xiangke Duan, Yang Fu, Liang Yang

Chapter 6 - Role of gene editing tool CRISPR-Cas in the management of antimicrobial resistance

A Parul Sarma, Chhavi Jain, Manu Solanki, Rajesh Ghangal, Soma Patnaik

Chapter 7 - Control of bacterial biofilms for mitigating antimicrobial resistance

Brij Pal Singh, Sougata Ghosh, Ashwini Chauhan

Chapter 8 - Intrusion of bacterial quorum-sensing for antimicrobial resistance mitigation: A pharmaceutical perspective

Sandeep Kumar, Shruti Shandilya, Kumar Siddharth Singh

Chapter 9 - Drug discovery for targeting drug resistant bacteria

Aikaterini Valsamatzi-Panagiotou, Katya B. Popova, Robert Penchovsky