Main description:

This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact.

Contents:

1. Application of Neutralization and Freeze-Drying Technique for the Preparation of the Beneficially in the Drug Delivery 2-Hydroxypropyl- -Cyclodextrin Complexes with Bioactive Molecules

Eirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis, Thomas Mavromoustakos, and Georgia Valsami

2. Functionalized Carbon Nanohorns as Drug Delivery Platforms

Anastasios Stergiou and Nikos Tagmatarchis

3. Ultrasonics-Assisted Effective Isolation and Characterization of Exosomes from Whole Organs

Burak Derkus and Emel Emregul

4. Aggregate Determination by Permeation Technique

Phennapha Saokham and Thorsteinn Loftsson

5. Study of Candesartan Cilexitil:2-Hydroxypropyl- -Cyclodextrin Interactions: A Computational Approach Using Steered Molecular Dynamics Simulations

Sofia Kiriakidi and Thomas Mavromoustakos

6. Drug Delivery: Hydrophobic Drug Encapsulation into Amphiphilic Block Copolymer Micelles

Angeliki Chroni, Varvara Chrysostomou, Athanasios Skandalis, and Stergios Pispas

7. Multisensitive Polymeric Nanocontainers as Drug Delivery Systems: Biological Evaluation

Maria Theodosiou, Theodora Koutsikou, and Eleni K. Efthimiadou

8. Drug Incorporation in the Drug Delivery System of Micelles

Evangelia Soumelidou, Simona Golic Grdadolnik, and Thomas Mavromoustakos

9. Molecular Dynamics Protocols for the Study of Cyclodextrin Drug Delivery Systems

George Leonis, Dimitris Ntountaniotis, Eirhnh Christodoulou, and Thomas Mavromoustakos

10. Drug Delivery through Multifunctional Polypeptidic Hydrogels

Hermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki, and Barbara Athanasiou

11. Polymersomes from Hybrids-Polypeptides for Drug Delivery Applications

Hermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki, and Barbara Athanasiou

12. Drug Delivery Systems Based on Modified Polysaccharides: Synthesis and Characterization

Aikaterini-Foteini Metaxa, Eleni Vrontaki, Eleni Efthimiadou, and Thomas Mavromoustakos

13. Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations

Nikolaos Naziris, Maria Chountoulesi, Dimitrios Ntountaniotis, Thomas Mavromoustakos, and Costas Demetzos

14. Encapsulation of Small Drugs in a Supramolecule Enhances Solubility, Stability, and Therapeutic Efficacy against Glioblastoma Multiforme

Antonis D. Tsiailanis, Alexander Renziehausen, Serdar Karakurt, Tim Crook, Nelofer Syed, and Andreas G. Tzakos

15. Unveiling the Thermodynamic Aspects of Drug-Cyclodextrin Interactions through Isothermal Titration Calorimetry

Maria V. Chatziathanasiadou, Thomas Mavromoustakos, and Andreas G. Tzakos

16. Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters

Ali Ben Taleb, Selcan Karakus, Ezgi Tan, Merve Ilgar , OEzlem Kutlu, Devrim Goezuacik, Hatice Mehtap Kutlu, and Ayben Kilislioglu

17. Association of the Thermodynamics with the Functionality of Thermoresponsive Chimeric Nanosystems

Nikolaos Naziris, Athanasios Skandalis, Thomas Mavromoustakos, Stergios Pispas, and Costas Demetzos

18. 2D DOSY NMR: A Valuable Tool to Confirm the Complexation in Drug Delivery Systems

Christos . Chatzigiannis, Sofia Kiriakidi, Andreas G. Tzakos, and Thomas Mavromoustakos

19. Drug-Encapsulated Cyclodextrin Nanosponges

Maria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani, Roberta Cavalli, and Francesco Trotta

20. Electrochemistry Investigation of Drugs Encapsulated in Cyclodextrins

Romana Sokolova and Ilaria Degano

21. A Differential Scanning Calorimetry (DSC) Experimental Protocol for Evaluating the Modified Thermotropic Behavior of Liposomes with Incorporated Guest Molecules

Maria Chountoulesi, Nikolaos Naziris, Thomas Mavromoustakos, and Costas Demetzos

22. Applications of NMR in Drug:Cyclodextrin Complexes

Dimitrios Ntountaniotis, George Leonis, Eirinh Christodoulou, and Thomas Mavromoustakos

23. Construction of Peptide-Drug Conjugates for Selective Targeting of Malignant Tumor Cells

Eirinaios I. Vrettos and Andreas G. Tzakos