Main description:

This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.

Contents:

STATs in Health and Disease
Clifford Liongue, Rowena S. Lewis, Alister C. Ward*
STAT Proteins in Cancer
Rachel A. O'Keefe, Jennifer R. Grandis*
Translating STAT Inhibitors from the Lab to the Clinic
Suhu Lui, David Frank*
Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials
Chao-Lan Yu, Richard Jove, James Turkson*
STAT3 Inhibitors in Cancer: A Comprehensive Update
Uddalak Bharadwaj, Moses M. Kasembeli, David J. Tweardy
Targeting Upstream Janus Kinases
Parisa Rasighaemi*, Alister C. Ward
Inhibitors of Upstream Inducers of STAT Activation
Janani Kumar*