Main description:

The International Life Sciences Institute (ILSI) was creat ed to promote cooperative efforts toward solving critical health and safety questions involving foods, drugs, cosmet ics, chemicals, and other aspects of the environment. The Officers and Trustees believe that questions regarding health and safety are best resolved when government and industry rely on scientific investigations, analyses, and re views by independent experts. Further, the scientific aspects of an issue should be examined and discussed on an international basis, separate from the political concerns of individual companies. ILSI is pleased to sponsor this set of monographs on the pathology of laboratory animals. This project will be use ful in improving the scientific basis for the application of pathologic techniques to health and safety evaluation of substances in our environment. The world wide distribu tion of the authors, editors, and Editorial Board who are creating these monographs strengthens the expectation that international communication and cooperation will al so be strengthened.

Contents:

The Upper Respiratory System (Nares, Larynx, Trachea).- Histology, Ultrastructure, Embryology.- Macrosopic, Microscopic, and Ultrastructural Anatomy of the Nasal Cavity, Rat.- Development of Syrian Golden Hamster Tracheal Epithelium During Prenatal and Immediate Postnatal Stages.- Epithelial Alterations in Explant Cultures of Fetal Tracheae of Syrian Golden Hamsters.- Neoplasms.- Response to Carcinogens of Respiratory Epithelium, Syrian Golden Hamster (Mesocricetus Auratus).- Polypoid Adenoma, Nasal Mucosa, Rat.- Neoplasms, Mucosa, Ethmoid Turbinates, Rat.- Squamous Cell Carcinoma, Nasal Mucosa, Rat.- Squamous Cell Carcinoma, Upper Respiratory Tract, Syrian Hamster.- Adenocarcinoma, Anterior Nasal Epithelium, Rat.- Hemangiosarcoma, Nasal Cavity, Mouse.- Clear Cell Carcinoma, Larynx, Syrian Hamster.- Lesions Due to Infections.- Murine Respiratory Mycoplasmosis, Upper Respiratory Tract, Rat.- Sialodacryoadenitis Virus Infection, Upper Respiratory Tract, Rat.- The Lung (Bronchi, Bronchioles, Alveolar Ducts, Alveoli, Pleura).- Histology and Ultrastructure.- Structure and Function of the Lung.- Neoplasms.- Bronchiolar/Alveolar Adenoma, Lung, Rat.- Alveolar Type II Cell Adenoma, Lung, Mouse.- Bronchiolar Adenoma, Lung, Mouse.- Bronchiolar/Alveolar Carcinoma, Lung, Rat.- Squamous Cell Carcinoma, Lung, Syrian Hamster.- Squamous Cell Carcinoma, Lung, Rat.- Radiation-Induced Squamous Cell Carcinoma, Lung of Rodents.- Pleural Mesothelioma, Syrian Hamster.- Metastatic Tumors, Lung, Mouse.- Nonneoplastic Lesions.- Bleomycin-Induced Injury, Mouse: A Model for Pulmonary Fibrosis.- Endogenous Lipid Pneumonia in Female B6C3F1 Mice.- Pulmonary Lipidosis, Rat.- Alveolar Lipoproteinosis, Rat.- Bronchiolar/Alveolar Hyperplasia, Lung, Rat.- Fly Ash Pneumoconiosis, Hamster.- Asbestosis, Hamster.- Pulmonary Hair Embolism.- Lesions Due to Infection.- Sendai Virus Infection, Lung, Mouse and Rat.- Rat Coronavirus Infection, Lung, Rat.- Pneumonia Virus of Mice Infection, Lung, Mouse and Rat.- Sialodacryoadenitits Virus Infection, Lung, Mouse.- Murine Respiratory Mycoplasmosis, Lung, Rat.- Pneumocystosis, Lung, Rat.- Aspergillosis and Mucormycosis, Lung, Rat.- Toxoplasmosis, Lung, Mouse and Hamster.