Main description:

Siegmund J. Baum It has become a tradition to commence advocated by Leonard Cole) (3). important meetings of this society with At about the same time, Alpen and reminiscence and nostalgia. Bone marrow Baum (4), using a larger mammal, the dog, transplantation, which has a history of only demonstrated that injecting autologous marrow 30 to 40 years, permits this process, since post irradiation would protect lethally some of the early investigators are still with irradiated animals (see Table). Certainly, us. For example, over the past 15 years, we protection was obtained from the cellular have had three symposia in honor of Egon constituents of the bone marrow. Lorenz. As we all know, the team of Lorenz, We undertook to test on dogs the Uphoff and Congdon was involved in the first hypothesis of Gengozian and Makinodum (5) that successful transplantation of syngeneic and increasing the radiation dose will increase allogeneic bone marrow into irradiated immunologic tolerance for allogeneic implants.

Contents:

I. Experimental Bone Marrow Transplantation.- 1 Graft-versus-Host Disease and Graft-versus-Leukemia in Experimental Systems.- 2 Syngeneic Graft-versus-Host Disease: Failure of Self: Non-Self Discrimination.- 3 Transfusion-Induced Allosensitization in Marrow Transplant Recipients: Mechanisms and Preventive Measures.- II. Experimental Bone Marrow Transplantation.- 4 Utilization of Monoclonal Antibodies for Autologous Bone Marrow Transplantation.- 5 Characterization of Malignant Lymphoma in Dogs and Use as a Model for the Development of Treatment Strategies.- 6 Hematopoietic Cell Transplantation in Murine Globoid Cell Leukodystrophy (The Twitcher Mouse)-A Model of a Human Sphingolipidosis (Krabbe Disease).- 7 Experimental Basis of Bone Marrow Purging with Chemical and Photodynamic Agents.- III. Leukemia.- 8 Oncogenes in Acute Myelogenous Leukemia.- 9 Optimal Timing of Marrow Transplantation for Patients with Acute Nonlymphoblastic and Acute Lymphoblastic Leukemia.- 10 Perspectives in Treatment of Adult Leukemia with High Dose Cytoreductive Therapy and Autologous Bone Marrow Treated Ex Vivo.- IV. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session A).- 11 Allogeneic and Autologous Marrow Transplants in Acute Nonlymphoblastic Leukemia (ANLL).- 12 Allogeneic Transplantation for Acute Lymphoblastic Leukemia.- 13 Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia-Mafosfamide Italian Study Group.- 14 Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia.- V. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session B).- 15 Autologous Marrow Transplantation for Hodgkin's and Non-Hodgkin's Lymphoma: Preliminary Results Using New Conditioning Regimens.- 16 Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells.- 17 Allogeneic Bone Marrow Transplantation for Leukemia-Japanese Experience.- VI. Aplastic Anemia.- 18 Allogeneic and Syngeneic Marrow Transplantation for Aplastic Anemia: Overview of Seattle Results.- 19 Recent Advances and Future Trends in Bone Marrow Transplantation for Severe Aplastic Anemia.- 20 Allogeneic Bone Marrow Transplantation in Leukemia.- VII. Acute Graft-versus-Host Disease.- 21 Bone Marrow Transplantation: The Difficulties Ahead.- 22 Predictive Models of Graft-versus-Host Disease.- 23 Prevention of Severe GVHD Employing Cyclosporine in HLA-Matched Marrow Transplant for Leukemia.- VIII. Chronic Graft-versus-Host Disease.- 24 Chronic Graft-versus-Host Disease: Pathogenesis, Diagnosis, Treatment and Prognostic Factors.- 25 The Role of Autoreactive T Lymphocytes in Graft-versus-Host Disease (GVHD).- 26 Predictive Factors for Chronic Graft-versus-Host Disease and Leukemic Relapse After Allogeneic Bone Marrow Transplantation.- IX. Infections After Bone Marrow Transplants.- 27 Viral Infection Following Bone Marrow Transplantation.- 28 Bacterial, Fungal, and Protozoan Infection After Marrow Transplantation.- 29 Prevention and Treatment of Infections after Bone Marrow Transplantation.- X. Metabolic and Genetic Disorders.- 30 Bone Marrow Transplantation for Thalassemia: 156 Cases Transplanted in Pesaro.- 31 Improvement of Clinical Expression of Central Nervous System Manifestation in Lysosomal Storage Diseases Treated By Bone Marrow Transplantation.- 32 Bone Marrow Transplantation Following Nuclear Accidents.- Conclusions.