This volume contains the proceedings of the Eighth International Symposium on Cyclodextrins, held in Budapest, Hungary, March 31-April 2, 1996.
The 147 papers collected here are milestones in the exponentially increasing cyclodextrin literature, and represent a summary of the last two years' achievement in this field, with applications in such diverse disciplines as pharmaceuticals, food, cosmetics, textiles, plastics, and chromatography.
Some highlights: lipophilicity profiles of cyclodextrins by computer molecular graphics; recent toxicological studies on cyclodextrins; Buckminsterfullerene/cyclodextrin complexes; hydroxypropyl-beta-cyclodextrin; pharmacokinetics and toxicology; peracylated cyclodextrins as drug carriers; cyclodextrins in nasal drug delivery; textile fibre surface modification by a reactive cyclodextrin; cyclodextrin-containing fabric care products; drug targeting by cyclodextrin-dimers for photodynamic cancer therapy; cyclodextrins in ophthalmologic drugs; new cyclodextrin derivatives and their potentials.
Audience: This book will be of interest to researchers whose work involves pharmaceuticals, food chemicals and flavours, food additives, chromatographic methods, and biotechnology, as well as fundamental cyclodextrin research.
Preface. 1: Cyclodextrins & Derivatives. 1.1. Structures, Physical-Chemical Properties. 1.2. Production of CDs. 1.3. Chemical Modification of CDs. 1.4. Biological Properties. 2: Cyclodextrin Inclusion Complexes. 2.1. Interaction with Specific Guests. 2.2. Structural Studies. 2.3. Enzyme-Modeling. 3: Cyclodextrins in Pharmaceuticals. 3.1. Drug/CD-Complexes. 3.2. Ocular, Nasal and Transdermal Delivery. 3.3. Specific Formulations. 3.4. Bioavailability and Biomedical Effects. 4: Industrial Applications of Cyclodextrins. 4.1. Biotechnology. 4.2. Textile Industry. 4.3. Food and Cosmetics. 4.4. Environment Protection and Chemical Technologies. 5: Analytical Separations by Cyclodextrins. Subject Index.