Main description:

Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor's increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance.To circumvent these difficulties, drug therapy targeting the tumor's specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.

Contents:

Introduction

Current dilemmas in the treatment of GI and liver cancers
Chemoradioresistance in GI Cancers
Tumor microenvironment against the action of chemotherapeutic drugs in GI cancer therapy
Role of phytochemicals on growth and metastasis of GI cancers
Combination of phytochemicals with chemotherapy on GI cancers cell death
Phytochemicals plus checkpoint inhibitors in GI cancers
Phytochemical analogues for the advancement of fourth generation therapeutic drugs for GI cancers
Phytochemicals on exosomes in GI cancers
The role of preventitive medicine and personalized care in overcoming cancer resistance and metastasis of GI cancers
Cancer stem cells as therapeutic targets for GI and liver cancers
Combination of phytochemicals with nanotechnology for targeting GI cancer therapy