Main description:

This detailed volume presents status and management protocols with the objective of identifying proper guidelines and materials for research related to the most common malignant neoplasm in the thyroid gland, papillary thyroid carcinoma. After an introduction, the book explores diagnostic approaches and initial surgical managements for patients with papillary thyroid carcinoma, guidelines for macroscopic examination, microscopic examination, and pathological staging, molecular approaches to this cancer, pathology laboratory approaches, as well as radiology oncology treatment protocols. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols that are readily reproducible, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Papillary Thyroid Carcinoma: Methods and Protocols serves as a vital resource for information on different aspects of the processes, cost, and resources available for the research and management of patients with papillary thyroid carcinoma.

Contents:

1. Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification

Alfred K. Lam

2. Assessment of Papillary Thyroid Carcinoma with Ultrasound Examination

Ichiro Abe and Alfred K. Lam

3. Fine Needle Aspiration under Guidance of Ultrasound Examination of Thyroid Lesions

Ichiro Abe and Alfred K. Lam

4. Thyroidectomy for Papillary Thyroid Carcinoma

Chung Yau Lo

5. Lymph Node Dissection for Papillary Thyroid Carcinoma

Chung Yau Lo

6. Macroscopic Examination of Surgical Specimen of Papillary Thyroid Carcinoma

Alfred K. Lam

7. Histopathological Assessment for Papillary Thyroid Carcinoma

Alfred K. Lam

8. Concepts of Pathological Staging and Prognosis in Papillary Thyroid Carcinoma

Alfred K. Lam

9. Liposomal siRNA Delivery in Papillary Thyroid Carcinoma Cells

Farhadul Islam, Yaoqi Zhou, and Alfred K. Lam

10. Long Non-Coding RNAs Profiling Using Microarray in Papillary Thyroid Carcinoma

Farhadul Islam, Yaoqi Zhou, and Alfred K. Lam

11. Single Nucleotide Polymorphisms in Papillary Thyroid Carcinoma: Clinical Significance and Detection by High Resolution Melting

Robert A. Smith and Alfred K. Lam

12. BRAF Mutations in Papillary Thyroid Carcinoma: A Genomic Approach Using Probe-Based DNA Capture for Next Generation Sequencing

Robert A. Smith and Alfred K. Lam

13. Application of Immunohistochemistry in Papillary Thyroid Carcinoma

Alfred K. Lam and Katherine Ting-Wei Lee

14. Whole-Slide Imaging: Updates and Applications in Papillary Thyroid Carcinoma

Alfred K. Lam, Alfa Bai, and Melissa Leung

15. External Radiotherapy for Loco-Regional Control in Thyroid Carcinoma

Dora L.W. Kwong and Wendy W.L. Chan

16. Radioactive Iodine for Papillary Thyroid Carcinoma

Wendy W.L. Chan and Dora L.W. Kwong

17. Radioiodine Refractory Differentiated Thyroid Cancer

Wendy W.L. Chan, Sonia Chan, and Dora L.W. Kwong