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MORE ABOUT THIS BOOK
Main description:
This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.
Contents:
Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects.- Chlorination and Nitration of DNA and Nucleic Acid Components.- Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides.- Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage.- OGG1: From Structural Analysis to the Knockout Mouse.- Processing of 3?-End Modified DNA Strand Breaks Induced by Oxidative Damage.- Oxidative Damage and Promoter Function.- Oxidative DNA Damage and Telomere Shortening.- Oxidative Damage and Repair in the Mitochondrial Genome.- The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease.- Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases.- Oxidative DNA Damage and Carcinogenesis.- The Physiological and Pathological Roles of Oxidative Damage to DNA in Relation to Life Stage.- Analysis of 8-Hydroxy-2?-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging.- Oxidatively Damaged DNA and Inflammation.- The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: July, 2011
Pages: 228
Weight: 385g
Availability: Available
Subcategories: Biochemistry
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