Main description:

Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However,itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches.
Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously,it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif*ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational,ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand&upportofArnallPatz, Bob Murphy, BertGlaser,RobertFrank,LarryHjelmeland,Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher,EphraimFriedman,MyronYanoff,MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama.
The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry,YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook.

Contents:

of the First Michaelson Medal Recipient.- The Isaac C. Michaelson Lecture.- 1: Blood Flow and Vein Occlusion.- Retinal fluorotachometry (dynamic fluorescein angiography).- Isovolemic hemodilution in ischemic and non-ischemic retinal vein occlusion.- O2 gradients in the miniature pig retina in normoxia and hyperoxia.- Ocular blood supply in internal carotid obstructions.- Retinal hemodynamics in diabetes mellitus.- Retinal artery emboli associated with mitral valve prolapse.- Development of retinal neovascularization in occlusive retinal vascular disease in adults.- Laser photocoagulation for retinal vein obstruction.- Prevention of clot formation in cat retinal vein by systemic and subconjunctival urokinase.- 2: Diabetic Retinopathy.- The formation and maintenance of new blood vessels.- Mechanism of elevated membrane formation and posterior vitreous detachment in diabetes mellitus.- Early photocoagulation of focal diabetic macular edema.- Photocoagulation for diabetic macular edema.- Juxtafoveal grid treatment with green monochromatic argon and with red krypton lasers for diabetic macular edema.- Acute diabetic retinopathies.- Angiogenic factors in human vitreous.- 3: Retinopathy of Prematurity.- The role of ischemia in the pathogenesis of retinal neovascularization.- Optimal strategy for ROP screening.- Influence of statistical methodology and composition of patient populations on the correlation of risk factors with ROP.- Retinopathy of Prematurity: Age at onset and the initial site of retinal involvement. A preliminary report.- Retinopathy of Prematurity: Treatment approaches.- Vitamin E at pharmacologic serum levels and incidence, progression and cicatricial residua of ROP..- Does Vitamin E have a protective role in the retina as an anti-oxidant and free radical scavenger?.- Retinopathy of Prematurity, past and present experience in Denmark.- "Rush type" retinopathy of prematurity (ROP) - a report of three cases.- A controlled study on the use of cryotherapy in prevention of retrolental fibroplasia (Retinopathy of prematurity).- The effect of cryotherapy on oxygen-induced retinopathy in the newborn kitten.- ROP in Soroka Medical Center Neonatal ICU.- 4: Age-Related Macular Degeneration.- Scleral rigidity, venous obstruction, and age-related macular degeneration: a working hypothesis.- Subfoveal choroidal neovascular membranes secondary to age-related macular degeneration: a review.- Zinc and copper metabolism study in patients with high myopia and senile macular degeneration.- Natural history of occult subretinal new vessels in age-related macular degeneration.- Monochromatic argon green laser in the treatment of juxtafoveal subretinal neovascularization (SRNV) in age-related macular degeneration (ARMD).- Laser treatment of occult subretinal new vessels in age-related macular degeneration: Feasibility study and comparison with natural history.- Argon laser treatment: randomized clinical trials, short and long-term results.- Perifoveolar laser treatment for subretinal new vessels in age-related macular degeneration.- Krypton red laser and argon green laser photocoagulation in the treatment of sick RPE due to age-related macular degeneration.- Senile serous detachment of RPE - Laser treatment: Controversial aspects.- Recurrent choroidal neovascularization following successful photocoagulation in age-related macular degeneration.- 5: Chronic Ocular Inflammation.- Evaluation of conventional therapy versus Cyclosporin A in Behcet's disease.- The effects of the cyclosporines on ocular inflammatory disease.- Lymphocyte activity and the role of humoral factors in patients with chronic ocular inflammation..- Antibodies to oral mucosa in patients with ocular Behcet's disease.- Best's vitelliform macular dystrophy subretinal neovascularization.- Pigment epitheliopathies - clinical and hematological changes.- Subretinal neovascularization of uncommon origin.- Vasculitis and morphology of microvilli of the conjunctiva in Sjogren syndrome.- 6: Neovascularization I - The Cornea.- Corneal neovascularization: an overview.- The rabbit cornea - a model for the study of angiogenic factors.- Immunologically mediated corneal neovascularization in inbred mice.- Vasoformative factor in the corneal epithelium.- Macrophage-induced neovascularization in the mouse eye: Correlation with other in vivo and in vitro tests of angiogenesis.- 7: Neovascularization II - The Iris and Angle.- Heterogeneity of vascular endothelial cells: its possible role in selective neovascularization in the eye.- Corneal endothelialization in experimental anterior synechias and rubeosis iridis.- Neovascular glaucoma: etiologic factors and management considerations.- Neovascular glaucoma after extracapsular cataract extraction in diabetic patients with diabetic retinopathy.- Cryotherapy for iris neovascularization and neovascular glaucoma.- Molteno implants in neovascular glaucoma.- 8: Neovsacularization III - Retina, RPE-Choriocapillaris.- Basement membranes and retinal neovascularization.- Localization of angiogenesis markers to inner and outer retina.- Pathological changes in retinal vasculature associated with hereditary retinal dystrophy in RCS-rats.- Retinal pigment epithelial tears and subretinal neovascularization.- Interactions between the retinal pigment epithelium and the choriocapillaris after krypton laser photocoagulation.- Mechanisms of lumen formation: morphologic observations on experimental subretinal neovascularization.- Animal model of RPE-choriocapillaris interactions: sodium iodate retinopathy in the rabbit.- Choroidal neovascularization and the retinal pigment epithelium.- Experimental evidence that capillaries influence RPE polarity.- Involution of subretinal neovascularization.- Choroidal vascular repair after krypton laser photocoagulation in the rat.- 9: Neovascularization IV - Angiogenesis Multiple Factors.- Growth characteristics of retinal microvascular cells in culture.- Storage of heparin-binding endothelial cell growth factors in the cornea: a new mechanism for corneal neovascularization.- The nontumor perspective: Angiogenesis and geometry in growth control.- Angiogenesis and interleukins.- The role of lactic acid in the mechanism of neovascularization.- Kinetics of activation of procollagenase by a low molecular weight mass, non protein angiogenic factor.- Retinal pigment epithelial cells inhibit vascular endothelial cells invasion.- A mitogenic factor or factors produced by cultured human retinal pigment epithelium cells.- Retinal pigment cells release inhibitors of neovascularization.- Inhibition of neovascular stimuli.- 10: Future Trends and Concepts.- A. Garner.- A. Patz.- G. Soubrane.- R. B. Nussenblatt.- M. Yanoff.- S. Ryan.- B. M. Glaser.- D. BenEzra.