Main description:

International experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity. The authors discuss in detail their diagnosis, clinical manifestations, complications, and best practices for diagnosis and treatment. They also review the history and epidemiology of these conditions, explain their genetics and pathophysiology, and illuminate their known mechanisms and interactions. State-of-the-art survey-chapters critique current approaches (lifestyle and pharmacological) to the treatment of these conditions.

Contents:

Part I. History and Epidemiology

Obesity and Diabetes: The Historical Events Marking the Evolution of the Understanding of the Pathophysiology and Treatment of Two Related Diseases
George Karanastasis and Christos S. Mantzoros

Epidemiology of Obesity and Diabetes: Prevalence and Trends
Susanna C. Larsson and Alicja Wolk

Part II. Genetics and Pathophysiology

Genetics of Obesity and Diabetes
Despina Sanoudou and Christos S. Mantzoros

Nutrients and Peripherally Secreted Molecules in Regulation of Energy Homeostasis
Greeshma K. Shetty, Diana Barb, and Christos S. Mantzoros

Central Integration of Peripheral Signals in Regulation of Energy Homeostasis
Greeshma K. Shetty, George Karanastasis, and Christos S. Mantzoros

Role of Energy Expenditure in Regulation of Energy Homeostasis
Eric S. Bachman

Pathophysiology of Diabetes in Obesity
Geetha R. Soodini and Osama Hamdy

Part III. Diagnosis, Clinical Manifestations, and Complications

Diagnosing Obesity, Diabetes Mellitus, and the Insulin Resistance Syndrome
Diana Barb and Christos S. Mantzoros

Metabolic Syndrome
Rochelle L. Chaiken and Mary Ann Banerji

Obesity, Diabetes, and Hypertension
Anjanette S. Tan, Stephen A. Brietzke, David W. Gardner, and James R. Sowers

Dyslipidemia Associated With Diabetes and Insulin Resistance Syndromes
Jody Dushay and J. Peter Oettgen

Obesity, Diabetes, and Endothelial Dysfunction
Geetha R. Soodini, Edward S. Horton, and Osama Hamdy

Atherosclerosis and Peripheral Vascular Disease: Sequelae of Obesity and Diabetes
Satish N. Nadig and Allen Hamdan

Obesity, Diabetes, and Risk of Cancer: A Review of Epidemiological Studies
Susanna C. Larsson, Hans-Olov Adami, and Alicja Wolk

Polycystic Ovary Syndrome and Its Metabolic Complications
Emilia P. Liao and Leonid Poretsky

Obesity and Type 2 Diabetes Mellitus in Childhood and Adolescence
Susann Bluher and Wieland Kiess

Diabetic Retinopathy
Vassiliki Poulaki and Joan W. Miller

Obesity and Renal Disease
Ayman Geneidy and Richard Solomon

Diabetic Peripheral Neuropathy
Rachel Nardin and Roy Freeman

The Diabetic Foot
Thanh L. Dinh and Aristidis Veves

Erectile Dysfunction
Kenneth J. Snow

Infections in Diabetes Mellitus
Sotirios Tsiodras, Iosif Kelesidis, Christos S. Mantzoros, and Adolf W. Karchmer

The HAART-Induced Metabolic Syndrome
Sotirios Tsiodras, Theodoros Kelesidis, and Christos S. Mantzoros

Part IV. Treatment

Diet and Lifestyle in the Prevention and Management of Type 2 Diabetes
Frank B. Hu

Diet, Exercise, and Behavioral Treatment of Obesity
George L. Blackburn

Medical Approaches to Treatment of the Obese Patient
George A. Bray and Donna H. Ryan

Medical Treatment of the Obese Patient With Type 2 Diabetes
Jean L. Chan, Christos S. Mantzoros, and Martin J. Abrahamson

Surgical Treatment of Obesity and Diabetes
Benjamin E. Schneider and Edward C. Mun

Future Developments in the Area of Pharmacotherapy: Molecules in Early-Stage Preclinical Development and in Clinical Trials That May Affect Energy Homeostasis
Diana Barb, Greeshma K. Shetty, and Christos S. Mantzoros

Index