BOOKS BY CATEGORY
Your Account
Next Generation Kinase Inhibitors
Moving Beyond the ATP Binding/Catalytic Sites
Price
Quantity
€134.19
(To see other currencies, click on price)
Paperback / softback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.


Contents:

Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors. [Paul Shapiro et al.]

Chapter 2: Overview of Current Type I/II Kinase Inhibitors. [Zheng Zhao, Philip E. Bourne]

Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors. [Paul Shapiro et al]

Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins. [Paul Shapiro et al.]

Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches [Yu et al.]

Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition [Rachel Sammons and Kevin Dalby]

Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases (Helton et al.)

Chapter 8: Novel peptide-based inhibitors of protein kinases [Justin Holub]


PRODUCT DETAILS

ISBN-13: 9783030482855
Publisher: Springer (Springer Nature Switzerland AG)
Publication date: July, 2021
Pages: 217
Weight: 361g
Availability: Available
Subcategories: Oncology

CUSTOMER REVIEWS

Average Rating