Main description:

This book helps to make sense of mitochondrial disease (Mito), an overwhelming and complex group of diagnoses that has grown exponentially in recent years. The most common metabolic disorder, thought to be more common than cystic fibrosis and broader-reaching than most genetic diseases, Mito can affect babies, children, and teens from birth or at any point during their development. Previously healthy adults, as well as adults with a history of unexplained fatigue, are increasingly receiving a Mito diagnosis. Some children with autism spectrum disorders who have medical issues such as digestive difficulties and fatigue are also being identified as having a mitochondrial disorder. This guide is the first book about Mito written for patients and their families. It takes readers from understanding how the mitochondria work (they are the powerhouse of the cell, providing energy for the entire body), how people with mitochondrial defects are diagnosed and treated, to how to live well when you, your child, or someone you love is struggling with disabling symptoms.
Topics include: the journey to diagnosis; the biochemistry of Mito; practical advice for the specific needs of children and adults; understanding and managing symptoms; where to find specialists and support; treatment approaches; and, autism and Mito. Writing from the perspective of both a parent and nurse, the author shows adult patients, parents, family members, and caregivers how to achieve the best quality of life possible. Readers will feel empowered as they come to understand the causes of Mito, learn to manage the symptoms, avoid emergencies, and make appropriate lifestyle choices.

Contents:

Preface; Measures of Coupling Strength & Synchronization in Non Linear Interaction of Heart Rate & Systolic Blood Pressure in the Cardiovascular Control System; Filtering Time Series Using Point-Wise Dimension: Application to the Study of Electrocardiograms; Non Periodic Cycles in Italian Financial Market; Noninvertible Maps & Complex Basin Boundaries in Dynamic Economic Models with Coexisting Attractors; Phase-Portrait in Conversation-Processes; Option Pricing: A Straightforward Procedure; The Riemann Magneton of the Primes; Self-Organized Power-Law Equilibrium Distributions in Structured Dynamical Systems; Climatic Memory; On the Complex Foundation of Ethics; Stability conditions in contextual emergence; Contextual emergence of mental states from neurodynamics; Phase coupling supports associative visual processing -- {Physiology} & related models; Processing of positive versus negative emotional words is incorporated in anterior versus posterior brain areas: {An ERP} microstate {LORETA} study; "Cognitive} genes"' reveal higher codon complexity than "somatic genes"; Mutual phase synchronization in single trial data; Ordinal analysis of {EEG} time series; Robustifying {EEG} data analysis by removing outliers; Is brain activity fractal?; The timing of neural processes in humans: {Beyond} the evoked potentials; Quantification of order patterns recurrence plots of event related potentials; Neuronal synchronization: {From} dynamic feature binding to object representations; Testing for coupling asymmetry using surrogate data; What can we learn from single-trial event-related potentials?; The internal structure of the {N400}: {Frequency} characteristics of a language related {ERP} component; Measuring the thalamocortical loop in patients with neurogenic pain; Assessment of connectivity patterns from multivariate time series by partial directed coherence; The cortical implementation of complex attribute & substance concepts: {Synchrony}, frames, & hierarchical binding.