Main description:

This book introduces readers to the principles of laser interaction with biological cells and tissues with varying degrees of organization. In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field. It discusses a range of mathematical modeling topics, including optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers; heating blood vessels using laser irradiation on the outer surface of the skin; and thermo-chemical denaturation of biological structures based on the example of human skin.

In this second edition, a new electrodynamic model of the interaction of laser radiation with blood cells is presented for the structure of cells and the in vitro prediction of optical properties. The approach developed makes it possible to determine changes in cell size as well as modifications in their internal structures, such as transformation and polymorphism nucleus scattering, which is of interest for cytological studies. The new model is subsequently used to calculate the size distribution function of irregular-shape particles with a variety of forms and structures, which allows a cytological analysis of the observed deviations from normal cells.

Contents:

Introduction 1 The main physical processes occurring in the interaction of optical radiation with matter

1.1 Introduction

1.2 Reflection and refraction

1.3 Absorption

1.4 Scattering

1.5 A Turbid media

References

2 Methods Describing the Interaction of Laser Radiation

with Biological Tissues

2.1 Introduction

2.2 The Structure and Optical Properties of Biological Tissues

2.3 The Structure and Optical Properties blood

References

Annotation. Here we consider the structure and optical properties of biological tissues, blood.

3 Overview of Theoretical Approaches to the Analysis

of Light Scattering

3.1 Introduction

3.2 Optical Properties of Tissues with Multiple Scattering

3.3 Stationary Theory of Radiative Transfer

3.4 Approximate Methods for Solving the Transport Equation

3.5 The Non-stationary Theory of Radiative Transfer 3.6 Methods for Measuring Optical Parameters of Biological Tissues

3.7 Methods for Solving Inverse Problems of Scattering Theory

3.8 Resume

References

Annotation. We propose methods of light scattering for the quantitative study

of the optical characteristics of the tissue, and the results of theoretical and

experimental studies of photon transport in biological tissues.

4 Study of optical Characteristics of Blood Formed Elements Using Intracavity Laser Spectroscopy

4.1 Introduction

4.2 Scattering by a particle with a shifted nucleus

4.3 The scattering cofficients

4.4 Scattering by a group of spherical objects

4.5 Numerical study of the Algebraic equations

4.6 Eigenmodes of the optical cavity with a cuvette filled with

spherical particles

4.7 Numerical analysis

4.8 Resume

References