Main description:

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Contents:

1. Overview of immune influence on the brain

The end of immune privilege Louveau A , US

Cytokines as brain signalling pathways Michael Maes/Brian Leonard

Immune system and neurodevelopment Michal Schwartz, Israel

Role of microglia in brain development Beth Stevens, US

Brain antigens and antibodies Laurent Groc, France

Complement and Major Histocompatibility Complex involvment in the brain Cai Song

Brain blood barrier Gerwyn Morris

Brain imaging to explore immune activation in the brain Lyliane Nasib, Utrecht, NL

2. Immune mechanisms and pathways leading to psychiatric disorders

Perinatal infections in psychiatric disorders Alan Brown, US

Auto-immune disorders as risk factors Michael Benros, Den

Role of cytokines in the psychiatric disorders Nicolas Glaichenhaus, France

Stress as a mediator of inflammation Carmine Pariante, UK

Role of Oxidative stress Ana Andreazza, Canada

Role of Endogenous retrovirus in psychiatry Herve Perron, France

Immuno-genetic background Ryad Tamouza, France

Gene-environment interactions Rudolf Uher

Gut to the brain John Cryan, UK

The complement pathway in the risk for schizophrenia Aswin Sekar, US

3. Immune dysfunctions and psychiatric disorders

Is Autism Spectrum Disorder related to immune dysfunction Van de Water, US

Inflammation and immunity in Schizophrenia Bob Yolken, US

Dysimmunity and Bipolar disorder Hemmo Drexhage, NL

Immune dysfunction and Major depressive disorder Robert Dantzer, US

Immune dysfunction and OCD Jose Oliveira

Is suicide a systemic disorder Lena Brundin, US

Is PTSD due to inflammation ? Raquel Yehuda, US

Inflammation in the neuro-circuitry of OCD Meyer JH , Toronto, Can

RDoC and inflammation Lucile Capuron, France

Bridging schizophrenia and autism through inflammation Cohelo R

The concept of auto-immune psychosis Bechter K, Germany

4. Immunotherapies for major psychiatric disorders

Veinoglobulins for the treatment of psychosis Belinda Lennox, UK

Monoclonal Antibiodies for major depressive disorder Tiago Reis-Marques, UK

Anti-inflammatory treatment for Traumatic Brain Injury Iris Sommer, NL

Rationale for using Cell therapies in Autism Spectrum Disorders E Gluckman and D Farges, FR

Probiotics in psychiatry : myth or reality ? Joel Dore, France

Statins and inflammation- new therapeutic opportunities in psychiatry Sung Wang Kim,

Cox inhibitors and aspirin as new treatments for psychiatric disorders Norbert Muller, Germany

Diet, immune system and psychiatric disorders Joe Frith/Jerome Sarris, Australia

Exercise and inflammation Brendan Stubbs, UK