Main description:

The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases.

Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas.

Key Features:

Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule

Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals

Presents flavonoid-based functional foods

Discusses the flavonoid nutraceuticals market and future trends

Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

Contents:

Flavonoids : Sources and Pharmacognastic Characterizations. Flavonoids Classification and Their Applications as Nutraceuticals. Basic NRF2 Physiology and Biochemistry. NRF2 and Oxidative Stress and Flavonoid Nutraceuticals. NRF2 Role in Health and Disease. NRF2 and Cancer and Flavonoid Nutraceuticals. NRF2 - Autophagy and Aging Flavonoid Nutraceuticals. NRF2 - Neurodegenerative Diseases and Brain Aging and Flavonoid Nutraceuticals. NRF2 and Ocular Aging and Flavonoid Nutraceuticals. NRF2 - Role in Obesity and Caloric Restriction and Flavonoid Nutraceuticals. NRF2 Cardiovascular Diseases and Aging and Flavonoid Nutraceuticals. NRF2 and Osteoporosis and Flavonoid Nutraceuticals. Flavonoid Nutraceuticals and Aging Populations. Flavonoids Based Functional Foods. Flavonoid Nutraceuticals Market and Future Trends.