Main description:

The International Life Sciences Institute (ILSI) was creat ed to promote cooperative efforts toward solving critical health and safety questions involving foods, drugs, cosmet ics, chemicals, and other aspects of the environment. The Officers and Trustees believe that questions regarding health and safety are best resolved when government and industry rely on scientific investigations, analyses, and reviews by independent experts. Further, the scientific aspects of an issue should be examined and discussed on an international basis, separate from the political concerns of individual companies. ILSI is pleased to sponsor this set of monographs on the pathology of laboratory animals. This project will be use ful in improving the scientific basis for the application of pathologic techniques to health and safety evaluation of substances in our environment. The world wide distribu tion of the authors, editors, and Editorial Board who are creating these monographs strengthens the expectation that international communication and cooperation will al so be strengthened.

Contents:

The Liver.- Anatomy, Histology, and Ultrastructure.- Embryology, Anatomy, Histology, and Ultrastructure of the Liver, Rat.- Neoplasms.- Foci of Altered Hepatocytes, Rat.- Histochemical Characteristics of Foci Induced by Diethylnitrosamine, Liver, Mouse.- Hepatocellular Carcinoma, Liver, Rat.- Hepatocellular Adenoma, Liver, Rat.- Cholangiofibroma and Cholangiocarcinoma, Liver, Rat.- Cholangioma, Liver, Rat.- Hemangiosarcoma, Liver, Rat.- Hemangioma, Liver, Rat.- Kupffer's Cell Sarcoma, Liver, Rat.- Focal Carcinoma in Hepatocellular Adenoma, Liver, Mouse.- Hyperplasia, Adenoma, Gallbladder, Hamster.- Nonneoplastic Lesions.- Polyploidy, Liver, Rat.- Intranuclear and Intracytoplasmic Inclusions, Liver, Rat.- Intranuclear and Intracytoplasmic Inclusions in Normal and Neoplastic Hepatocytes, Mouse.- Extramedullary Hematopoiesis, Liver, Rat.- Nutritional Fatty Liver and Cirrhosis, Rat, Mouse.- Cirrhosis, Mouse.- Peliosis Hepatis, Rodents.- Spongiosis Hepatis, Rat.- Hyperplasia, Diffuse, Following Partial Hepatectomy, Mouse.- Oval Cell Hyperplasia, Liver, Mouse, Rat.- Herniation of Liver Through Esophageal Hiatus, Rat.- Viral Infections.- K Virus Infection, Liver, Mouse.- Mouse Hepatitis Virus Infection, Liver, Mouse.- Rat Parvovirus Infection, Liver.- Mousepox, Liver, Mouse.- Reovirus Type 3 Infection, Liver, Mouse.- Bacterial Infections.- Tyzzer's Disease, Liver, Mouse, Rat, Hamster.- Corynebacterium Kutscheri Infection, Liver, Mouse and Rat.- Salmonellosis, Liver, Mouse, Rat, Hamster.- The Salivary Glands.- Histology and Ultrastructure, Salivary Glands, Mouse.- Neoplasms.- Myoepithelioma, Salivary Glands, Mouse.- Adenoma, Adenocarcinoma, Salivary Gland, Mouse.- Polyoma Virus Infection, Salivary Glands, Mouse.- Nonneoplastic Lesions.- Cytomegalovirus Infection, Salivary Glands, Mouse, Rat, Hamster.- Sialodacryoadenitis (SDA) Infection, Rat.- The Exocrine Pancreas.- Histology and Ultrastructure.- Embryology, Histology, and Ultrastructure of the Exocrine Pancreas.- Neoplasms.- Acinar-Cell Carcinoma, Pancreas, Rat.- Experimental Carcinogenesis of Exocrine Pancreas: Animal Models, Neoplasms, and Current Understanding of Pathogenesis.- Nonneoplastic Lesions.- Atrophy, Exocrine Pancreas, Rat.- Exocrine Pancreas of Hypophysectomized Rats.- Necrotizing Pancreatitis Induced by 4-HAQO, Rat.- The Gastrointestinal Tract.- 1. Oral Cavity.- Squamous Cell Carcinoma, Tongue, Rat.- 2. Esophagus.- Neoplasms.- Squamous Cell Papilloma, Esophagus, Rat.- Carcinoma In Situ, Esophagus, Rat.- Squamous Cell Carcinoma, Esophagus, Rat.- Papilloma and Squamous Cell Carcinoma, Esophagus, Rat (Zinc Deficiency, Alcohol, and Methylbenzylnitrosamine).- 3. Stomach.- Anatomy, Histology, Ultrastructure, Stomach, Rat.- Neoplasms.- Papilloma, Forestomach, Rat.- Squamous Cell Carcinoma, Forestomach, Rat.- Adenoma, Stomach, Rat.- Adenocarcinoma, Glandular Stomach, Rat.- Leiomyoma and Leiomyosarcoma, Stomach, Rat.- 4. Small Intestines.- Viral Infections.- Mouse Hepatitis Virus Infection, Intestine, Mouse.- Murine Rotavirus Infection, Intestine, Mouse.- Adenovirus Infection, Intestine, Mouse.- K Virus Infection, Intestine, Mouse.- Bacterial Infections.- Tyzzer's Disease, Intestine, Mouse, Rat, Hamster.- Salmonellosis, Intestine, Mouse, Rat, Hamster.- Citrobacter freundii Infection, Colon, Mouse.- Clostridial Enteropathies, Hamster.- Transmissible Ileal Hyperplasia, Hamster.- Helminth and Protozoal Infections.- Spironucleus Muris Infection, Intestine, Mouse, Rat, Hamster.- Giardia Muris Infection, Intestine, Mouse, Rat, Hamster.- 5. Large Intestine.- Neoplasms.- Adenocarcinoma, Colon and Rectum, Rat.