Main description:

This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

Contents:

Chapter 1: Central Axonal Development and Pathology in Early Life
Robin L. Haynes, Hannah C. Kinney

Chapter 2: Microtubules in the nervous system
Nobuyuki Fukushima

Chapter 3: Tau phosphorylation
Jesus Avila, Felix Hernandez

Chapter 4: Tau Pathology
Nicolas Sergeant, Luc Buee

Chapter 5: Tauopathy and brain aging
Akihiko Takashima

Chapter 6: Microtubule-associated protein 4
Kiyotaka Tokuraku, Kazuyuki Matsushima, Hiroyuki Nakagawa, Susumu Kotani

Chapter 7: Structure of Neural Intermediate Filaments
David A.D. Parry

Chapter 8: Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNS
Aidong Yuan, Ralph A. Nixon

Chapter 9: Peripherin Pathology
Jesse R. McLean, Janice Robertson

Chapter 10: Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family
Takahiro Gotow

Chapter 11: Neurofilament Transport
Andrew J Grierson and Christopher C.J Miller

Chapter 12: Knockout models of neurofilament proteins
Rodolphe Perrot, Jean-Pierre Julien

Chapter 13: Neurofilaments and Radial Growth: Deconstruction of a hypothesis through the construction of gene targeted mice
Michael L. Garcia, Devin M. Barry

Chapter 14: Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration
Jyotshnabala Kanungo, Ya-li Zheng, Parvathi Rudrabhatla, Niranjana D. Amin, Bibhutibhushan Mishra, Harish C. Pant

Chapter 15: Neurofilaments in Aged Animals
Shin-ichi Hisanaga, Takahiro Sasaki, Atsuko Uchida

Chapter 16: Neurofilament changes in Multiple Sclerosis
Elizabeth Gray, Alastair Wilkins

Chapter 17: Intermediate filament interactions in neurons
Kevin G. Young, Rashmi Kothary

Chapter 18: Tropomyosins in Neuronal Morphogenesis and Development
Nikki Margarita Curthoys, Peter William Gunning, Thomas Fath

Chapter 19: The Driving Machinery for Growth Cone Navigation
Takuro Tojima, Hiroyuki Kamiguchi

Chapter 20: Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytes
Douglas L. Eng, Lawrence F. Eng

Chapter 21: Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation
Aidong Yuan, Ralph A. Nixon

Chapter 22: Axonal transport and motor neuron disease
Anna-Lena Stroem, Lawrence J. Hayward, Edward J. Kasarskis, Haining Zhu

Chapter 23: In vivo imaging of axonal transport in aging and Alzheimer's disease
Donna J. Cross, Satoshi Minoshima

Chapter 24: Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease
Ben G. Szaroa, Michael J. Strong

Chapter 25: Crosstalks between myelinating cells and the axonal cytoskeleton
Rodolphe Perrot, Joel Eyer

Chapter 26: Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and disease
Parvathi Rudrabhatla, Harish C Pant

Chapter 27: Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy
Hsinlin T Cheng, Brian Callaghan, Jacqueline R Dauch and Eva L Feldman

Chapter 28: Effects of Insulin on Tau and Neurofilament
R. Schechter, K.E. Miller

Chapter 29: Ethanol effects on the cytoskeleton of nerve tissue cells
Sergio G. Evrard, Alicia Brusco