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Main description:
Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
Contents:
Part I. Cytokine Knockouts in Models of Human Disease
Cytokine Knockouts in Inflammation
Pietro Ghezzi
The Use of Cytokine Knockouts to Study Host Defense Against Infection
Charles A. Dinarello
The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease
Alfons Billiau, Hubertine Heremans, and Patrick Matthys
The Use of Cytokine Knockout Mice in Cancer Research
Robert H. Wiltrout, Jon M. Wigginton, and William J. Murphy
The Use of Cytokine Knockout Mice in Neuroimmunology
Giamal N. Luheshi, Emmanuel Pinteaux, and Herve Boutin
Part II. Cytokine Knockout Mice
The Role of IL-1 in the Immune System
Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane, and Yoichiro Iwakura
IL-1 Receptor Antagonist-Deficient Mice
Martin J. H. Nicklin and Joanna Shepherd
A Unique Role for IL-2 in Self-Tolerance
Thomas Hunig and Anneliese Schimpl
Molecular Basis for Binding Multiple Cytokines by gc: Implications for X-SCID and Impaired gc-Dependent Cytokine Receptor Function
Ferenc Olosz and Thomas R. Malek
G-CSF, GM-CSF, and IL-3 Knockout Mice
Thomas Enzler and Glenn Dranoff
IL-4 Knockout Mice
Pascale Kropf and Ingrid Muller
Role of IL-5 in Immune and Pathological Responses in the Mouse
Paul S. Foster and Simon P. Hogan. IL-6 Knockout Mice, Valeria Poli and Diego Maritano
IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation
Karen L. Madsen and Humberto Jijon
IL-12-Deficient Mice
Luciano Adorini
IL-13 and Double IL-4/IL-13 Knockout Mice
Duncan R. Hewett and Andrew N. J. McKenzie
IL-15: Insights from Characterizing IL-15-Deficient Mice
Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, and Mary K.Kennedy
IL-18 and IL-18 Receptor Knockout Mice
Hiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, and Kenji Nakanishi
Mice Knockouts for Chemokines and Chemokine Receptors
Jane M. Schuh, Steven L. Kunkel, and Cory M. Hogaboam
IFN-g and IFN-g Receptor Knockout Mice, Dyana Dalton
Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice
Gunter Fingerle-Rowson, Abhay R. Satoskar, Richard Bucala
Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice
Susan R. Rittling, Anthony W. O'Regan, and Jeffrey S. Berman
RANKL, RANK, and OPG
Young-Yun Kong and Josef M. Penninger
Targeting the TGF-b Pathway In Vivo: Defining Complex Roles for TGF-b Signaling in Immune Function, Wound Healing, and Carcinogenesis
Lawrence Wolfraim, Mizuko Mamura, Anita Roberts, and John J. Letterio
Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models
Sergei A. Nedospasov, Sergei I. Grivennikov, and Dmitry V. Kuprash
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 492
Weight: 927g
Availability: Available
Subcategories: Immunology
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