Main description:

Animal models varying from mammals to flies and worms are widely used in studying human diseases. These models share homolog genes as expressed in human disease conditions, helping to elucidate mechanisms and pathways of these diseases in different organs of the animals, which might be difficult to assess in clinical-based research. This book provides scientific reports on therapeutic potentials of medicinal plants in different animal models and provides information on the beneficial roles of the medicinal plants on human diseases.

The chapters look at number of different medicinal plants in conjunction with several different animal models, examining the medicinal properties and activities of the plants for a variety of health issues, such as for diabetes, cardiovascular disease, neurodegenerative disease, organ dysfunctions, cancer, for labor and postpartum issues, and more. The therapeutic mechanism of some phytoconstituents is also discussed.

This important compendium provides valuable information for researchers and scientists involved in drug delivery and development, pharmacognosy, pharmacology, and biochemistry.

Contents:

PART 1: POTENTIAL OF MEDICINAL PLANTS IN METABOLIC DISEASES 1. Leaf Extract of Dombeya buettneri for Inhibition of Inflammatory Cytokines Aggregation in Type-2 Diabetes 2. Antidiabetic Potential of African Medicinal Plants: A Brief Review Using Animal Models 3. In vitro Antioxidant and Nephroprotective Activities of Carica papaya Methanol Extracts Using Streptozotocin-Induced Diabetic Male Albino Rats 4. Potential of Moringa oleifera for Prevention of Cardiovascular Diseases in Animal Models 5. Blood Sugar Regulation and Pro-Inflammatory Effects of Desplatsia dewevrei in Streptozotocin-Induced Diabetic Wistar Rats PART II: POTENTIAL OF MEDICINAL PLANTS IN NEURODEGENERATIVE DISEASES 6. Plant-Based Antioxidants in the Prevention and Treatment of Neurodegenerative Diseases: Pros and Cons 7. Neuroprotective Efficacy of Ethnomedicinal Plants in Mental Disorders with Animal Models 8. Translational Neuroprotective Activity of Curcumin in Neurodegenerative Diseases: An Overview with Animal Models PART III: POTENTIAL OF MEDICINAL PLANTS IN ORGAN DYSFUNCTIONS 9. Multiple Organ Dysfunction Syndrome: Phytotherapeutic Evidence from Intestinal Ischemia-Reperfusion Models 10. Biochemical Constituents and Toxicological Effects of Syzygium aromaticum on Selected Organs in Male Wistar Rats 11. Therapeutic Mechanisms of Bioactive Compounds in Lipopolysaccharide-Induced Liver Injury with Murine Models 12. Telfairia occidentalis for the Alteration of Expression Ratio of Bax/Bcl-2 mRNA in Lead-Exposed Rat Testicular Tissues PART IV: HEALTH BENEFITS OF MEDICINAL PLANTS 13. Hydro-Ethanolic Leaf Extract of Parquetina nigrescens: Hematological Indices and Biochemical Parameters in Male Wistar Rats 14. Role of Phytochemicals in Allium sativum on Obesity: A Review 15. Antidiabetic Potency of Tofu (Soybean Meal) 16. Antioxidant Potential of Seed and Leaf Extracts of Adansonia digitata 17. Antioxidant, Anti-inflammatory, and Thrombolytic Activities of Monodora tenuifolia, Benth Seed Extract 18. Effects of Taraxacum officinale Extract on Hematological Parameters in Female Wistar Rats with Ethanol-Induced Toxicity 19. Antimutagenic Activity of Moringa oleifera Seeds 20. Scope of Medicinal Plants for Uterotonic, Tocolytic, and Wellness Effects in Pregnant Women: A Cultural Perspective 21. Role of Phytonutrients in Chemoprevention of Cancer: A Review