Main description:

Examining the complex interactions associated with clinical toxicological events and chemical exposure of drug administration, this updated and revised Second Edition functions as a stand-alone text or reference of clinical toxicology for professionals, students of toxicology and pharmacy, as well as forensic toxicologists, occupational healthcare workers, industrial hygienists, and safety engineers. This all-inclusive source has been updated to include the latest issues and the most current research in clinical toxicology.

Key features in Clinical Toxicology: Principles and Mechanisms include:

• Convenient and organized categorization of compounds into therapeutic and non-therapeutic agents


• Tables, drawings, and figures that provide readily accessible, precise data


• Tables for easy usage and cross-reference to names, indications, effects, adverse reactions, and drug interactions for over 70 common herbal products


• The brand, generic, and street names of therapeutic agents

Topics covered in the Second Edition include:

• Symptoms of diseases and pathology caused by toxins and clinical drugs


• Biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, changes in treatments, and the pharmacology and toxicology of herbal products


• The effects of biological and chemical agents cited by the U.S. and U.N. as potential bioterrorist weapons


• General physiology and pharmacology principles


• The widely distributed chemical agents and currently used therapeutic drugs that have hazardous effects

Contents:

Preface
Acknowledgments
Contributors

Introduction to Basic Toxicological Principles
Introduction
Risk Assessment and Regulatory Toxicology
Therapeutic Monitoring of Adverse Drug Reactions
Classification of Toxins in Humans
Exposure
Effects
Dose Response
Descriptive Animal Toxicity Tests
In Vitro Alternatives to Animal Toxicity
Toxicokinetics
Chemical and Drug Receptor Interactions-Zacharoula Konsoula
Toxicogenomics-Zacharoula Konsoula

Toxicity of Therapeutic Agents
Sedative/Hypnotics
Opioids and Derivatives
Sympathomimetics
Hallucinogenic Agents
Anticholinergic and Neuroleptic Drugs
Acetaminophen, Salicylates, and Nonsteroidal Anti-inflammatory Drugs
Anabolic-Androgenic Steroids
Cardiovascular Toxicology
Antineoplastic Agents
Vitamins
Herbal Remedies

Toxicity of Non-Therapeutic Agents
Alcohols and Aldehydes
Gases
Metals-Louis D. Trombetta and Frank A. Barile
Aliphatic and Aromatic Hydrocarbons
Insecticides
Herbicides
Rodenticides
Chemical Carcinogenesis and Mutagenesis
Reproductive and Developmental Toxicity
Radiation Toxicity
Chemical and Biological Threats to Public Safety
Index