Main description:

The International Union Against Can- knowledge of what to do or how to do it; cer convened a Conference on the to identify the nature of, and reason for, Chemotherapy of Choriocarcinoma in the successful chemotherapeutic results in Baguio City, Philippines to focus atten- trophoblastic neoplasia (whether this be tion on the therapy of neoplasms of the specificity of drugs, the nature of the trophoblast. allogenic graft or characteristics of the Cures of cancer are of concern to every specific cells); and to determine the cau- man. The oldest therapy of cancer likely ses for failures (whether it be advanced consisted of herbs, potions and incanta- and long-standing disease, inappropriate tions. Cures may first have been achieved dosage regimens, or inherent resistance of in the murky annals of early civilization the tumors treated). If this first chemo- with local chemical cautery. The first therapeutically curable cancer can serve successes of surgery are lost in antiquity as a model for the chemotherapy of other and probably were amputations.
Radia- autochthonous tumors, the therapeutic tion therapy was first used for cure in the principles may be useful for extrapolation early years of the 20th century. Curabil- to other tumors. Such unique maracteris- ityof the first cancer with drugs is a recent tics as the temnique of dosing and the phenomenon: choriocarcinoma in 1956.

Contents:

The Pathology of Trophoblastic Tumours.- Transplantation Immunity and the Trophoblast.- Alternations of the Thymo-Lymphatic System in Malignant Trophoblastic Disease.- Serial Passage of Choriocarcinoma of Women in The Hamster Cheek-Pouch.- Synopsis of discussion I.- Trophoblastic or Chorionic Tumors as Observed in the Philippines.- The Natural History of Choriocarcinoma.- Early Development of Choriocarcinoma.- A Study of Choriocarcinoma. Its Incidence in India and Its Aetiopathogenesis.- Observation on Some Aspects of Hydatidiform Mole and Choriocarcinoma in Indonesia.- Synopsis of discussion II.- The Mechanism of Action of Folic Acid Antagonists.- Eight Years Experience with the Chemotherapy of Choriocarcinoma and Related Trophoblastic Tumors in Women.- On the Prevention and Treatment of Choriocarcinoma.- Chemotherapeutic Prophylaxis Against the Development of Choriocarcinoma Following the Removal of Hydatidiform Mole.- An Observation on the Prophylactic Use of Chemotherapy After Termination of Hydatidiform Mole.- The Effect of Methotrexate in Trophoblastic Diseases.- Methotrexate Treatment in Choriocarcinoma (Preliminary Report).- Synopsis of discussion III.- Urinary Excretion of Gonadotropin and the Estrogens in Hydatidiform Mole and Choriocarcinoma.- Endocrinological Studies Relating to Trophoblastic Disease in Man.- Pelvic Angiography in the Management of Malignant Trophoblastic Disease.- Diagnosis of Hydatidiform Mole and Related Trophoblastic Diseases. A Further Study of the Galli-Mainini Bioassay Test.- Comments on the Measurement of HCG as a Tumor Specific Substance.- Urinary Estrogen Excretion in Chorionic Tumor Patients.- Quantitative Human Chorionic Gonadotropin Immunoassay.- Synopsis of discussion IV.- Chemotherapy of Chorionic Tumors.- The Use of 6-Mercaptopurine with Methotrexate in the Treatment of Trophoblastic Tumors.- Remissions Induced in Patients with Trophoblastic Tumors by 6-Diazo-5-Oxo-L-Norleucine (DON).- Fundamental Problems of Chemotherapy of Choriocarcinoma.- Clinical Effects of Vinblastine in Chorionic Tumors.- The Clinical Evalution of Various Anticancer Agents on Chorionic Tumors.- Chemotherapeutic and Immunological Considerations on the Response of Choriocarcinomas.- Synopsis of discussion V.- Integration of Treatment Methods in Trophoblastic Growths.- Synopsis of discussion VI.- Appendix I.- Appendix II.- Appendix III.