The scientific main programmes of these series of symposia changed from time to time following the international scientific trends. The main programmes of the First Symposium were: 1. Gastric and intestinal cytoprotection; 2. Hepatoprotection; 3. Pancreatic protection. For the second one: 1. Gastrointestinal mucosal 'cytoprotection'; 2. Liver 'cytoprotection'; 3. Pancreatic 'cytoprotection'; 4. Free radicals and scavangers; 5. Computer approach to cytoprotec tion. For the third one: 1. Basic, central, peripheral and cellular mechanisms of gastrointestinaol cytoprotection; 2. Esophagal protection; 3. Gastric protection; 4. Small intestinal injury and protection; 5. Large bowel injury and protection; 6. Liver injury and protection; 7. Pancreas injury and protection. The main scientific programmes of the Fourth International Symposium on 'Cell Injury and Protection in the Gastrointestinal Tract' are: 1. General mechanisms of gastrointestinal injury and protection; 2. Cell injury and protection in the stomach; 3. Cell injury and protection in the small intestine and in the large bowel; 4. Cell injury and protection in the liver and pancreas; 5. Cell injury and protection of the premalignant status and malignant diseases in the gastrointestinal tract. The presented papers are published in this book. The abstracts of this meeting were published in Digestive Diseases and Sciences, and we record appreciation of the Editor ofthatjoumal for their publication. Some of the papers published here have appeared in Inflammopharmacology 1996;4:331-398.
Preface. Emerging Research in Gastrointestinal Diseases; K.D. Rainsford. I. General Mechanisms of Gastrointestinal Diseases. Analyses of Pathogenic Elements Involved in Gastric Lesions Induced by Indomethacin in Rats; K. Takeuchi, et al. NO-NSAID: A Novel Class of Anti-Inflammatory Drugs with Reduced Gastrointestinal and Renal Toxicity; P. Del Soldato, et al. Gastric Mucosal Preventive Effects of Prostacyclin and Beta-Carotene, and Their Biochemical Effects in Rats Treated with Ethanol and HCL in Dependence of Their Doses and of Time After Administration of Necrotizing Agents; G. Mózsik, et al. Reduction in Gastric Bicarbonate Secretory Response Induced by NG-nitro-L-Arginine Methyl Ester Following the Repeated Administration in Rats; K. Takeuchi, et al. Role of Basic Fibroblast Growth Factor (bFGF) and Platelet-Derived Growth Factor (PDGF) in Ulcer Healing; S. Szabo, et al. The Response of Odontoblasts on the Injury of Epithelial Integrity; J. Szabo, G. Varbiro. Analysis of Receptor-Mediated Gastric Cytoprotection; K. Gyires. II: Cell Injury and Protection in the Stomach. The Effect of Intragastric Capsaicin and Resiniferatoxin on the Indomethacin-Induced Gastric Mucosal Damage in Rats; O.M.E. Abdel Salem, et al. A Comparative Study on the Adenine Nucleotide Metabolism of the Acid-Dependent and Nonacid-Dependent Acute Gastric Mucuosal Injury in Rats; B. Gasztonyi, et al. Morphological Aspects of BPC Protection in Ethanol-Induced Gastric Lesions in Rats; S. Seiwerth, et al. Inhibitory Effect of Omentopexy on Experimental Chronic Gastric Antral Formation; B.S. Dunjic, et al. Effect of Suramin on Ethanol-Induced Gastric Mucosal Injury: Relationship Between Tissue Distribution and Severity of Damage; C. Blandizzi, et al. Effects ofRanitidine, Omeprazole and Vagotomy on Rat Gastric Mucosal Phospolipids; B.S. Dunjic, et al. Are Phospholipids Involved in Gastroprotective Capacity of Avocado? B.S. Dunjic, et al. Transmucosal Potential Difference as a Marker of Helicobacter pylori Induced Gastric Mucosal Barrier Damage; I. Racz, et al. Impaired Gastric Mucosal Defense in Helicobacter pylori Related Conditions; M. Jablonska. The Role of Cysteine and Serine Proteases in Gastric Carcinogenesis and Their Prognostic Impact in Gastric Cancer; L. Herszenyi, et al. Inhibition of Rabbit Gastric Epithelial Restoration by a Water Extract of Helicobacter pylori: Evidence Using a Cultured Cell Model; N. Sato, et al. III: Cell Injury and Protection in Small Intestine and in The Large Bowel. Zinc Sulphate Healing Effects on Cysteamine-Induced Duodenal Ulcer in the Rat; B. Troskot, et al. Endogenous Vasopressin Damages Duodenal Mucosa During Haemorrhagic Shock in Rats; F. Laszlo, et al. The Vascular Event as a Target in the Changes of the Indomethacin-Induced Gastrointestinal Mucosal Damage After Acute Surgical and `Chemical' Vagotomy in Rats; O. Karadi, et al. Involvement of Corticotropin Releasing Factor (CRF) and Vasopressin (AVP) in Stress-Induced Exacerbation of Experimental Colitis in Rats; M. Gue, et al. Protective Effect of Trapencaine in Acetic Acid-Induced Colitis in Rats; V. Nosalova, V. Bauer. Pentadecapeptide BPC157 Beneficially Influences the Healing of the Colon-Colon Anastomosis in Rats; P. Sikiric, et al. Cysteine and Serine Proteases in Duodenal Ulcer; L. Herszenyi, et al. IV: Cell Injury and Protection in the Liver and in the Pancreas. Treatment of Chronic Liver Disease. Do Cytoprotective Agents Interfere with Drug-Metabolizing Act