Main description:

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Contents:

Defective Apoptosis Signaling in Cancer.- The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells.- Emerging Opportunities for Targeting the Tumor-Stroma Interactions for Increasing the Efficacy of Chemotherapy.- The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting.- microRNAs in Cell Death and Cancer.- Targeting DNA Repair Pathways for Cancer Therapy.- Molecular Chaperones and How Addiction Matters in Cancer Therapy.- Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment.- Leading Small Molecule Inhibitors of Anti-apoptotic Bcl-2 Family Members.- SMAC IAP Addiction in Cancer.- Harnessing Death Receptor Signaling for Cancer Treatment.- Proteasome Inhibition as a Novel Strategy for Cancer Treatment.- New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways.- Activation of Immune-Mediated Tumor Cell Death by Chemotherapy.