Main description:

Bone Metastases: A Translational and Clinical Approach serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume:

describes the molecular and cellular mechanisms involved in the formation of bone metastases,
comments on the role of angiogenesis,
presents the newer advances made in the understanding of the clinical picture and symptoms of patients,
analyses the role of bone markers in research and clinical practice
deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases.

This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease.

Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Contents:

Part I: Fundamental concepts of bone metastases

1. Bone anatomy, physiology and function; Vassiliki Tzelepi, Athanassios C. Tsamandas, Vassiliki Zolota and Chrisoula D. Scopa

2. Pathophysiology of bone metastases; G. David Roodman

3. Angiogenesis and bone metastases: Implications for diagnosis, prevention and treatment; Pelagia G. Tsoutsou and Michael I. Koukourakis

4. Natural history, prognosis, clinical features and complications of metastatic bone disease; Vassilios Vassiliou, Edward Chow and Dimitrios Kardamakis

5. Bone biomarkers in research and clinical practice; Janet E. Brown and Edward Chow

Part II: Imaging modalities

6. Radiologic evaluation of skeletal metastases: role of plain radiographs and computed tomography; Christina Kalogeropoulou, Anna Karachaliou and Petros Zampakis

7. The contribution of nuclear medicine in the diagnosis of bone metastases; Andor W.J.M., Glaudemans, Marnix G.E.H. Lam, Niels C. Veltman, Rudi A.J.O Dierckx, and Alberto Signore

8. Magnetic resonance imaging of metastatic bone disease; Ekaterini Solomou, Alexandra Kazantzi, Odysseas Romanos and Dimitrios Kardamakis

Part III: Therapeutic strategies

9. Radiotherapy and bone metastases; Jan W.H. Leer and Yvette M. van der Linden

10. Biphosphonates in the management of metastatic bone disease; Fred Saad and Arif Hussain

11. Combined radiotherapy and biphosphonates: state of art; Vassilios Vassiliou and Dimitrios Kardamakis

12. Biphosphonates in the treatment of bone metastases - Osteonecrosis of the jaw; Cesar Augusto Migliorati

13. Surgical management of bone metastases; Markku Nousiainen, Cari M. Whyne, Albert J.M. Yee, Joel Finkelstein and Michael Ford

14. The role of chemotherapy in the treatment of bone metastases; Thomas Makatsoris and Haralabos P. Kalofonos

15. Hormonotherapy of bone metastases; Konstantinos Kamposioras and Evangelos Briasoulis

16. Radionuclide therapy; Giovanni Storto

Part IV: Assessment of therapeutic response

17. Assessement of therapeutic response; Orit Freedman, Mark Clemons, Vassilios Vassiliou, Kardamakis Dimitrios, Christine Simmons, Mateya Trinkaus and Edward Chow

18. Outcome measures in bone metastases clinical trials; Amanda Hird and Edward Chow