Main description:

Writing or editing a book on a very topical field of science is always a great challenge,since by the time the book is published some of the newest and latest findings might be obsolete compared with results reported in the most current issues of various high-level journals. Nevertheless,stimulating good books describe complicated systems and int- relationships and provide a broad spectrum of material for talented researchers who may find new inspiration from a joint presentation of correlated data. Of course,an editor cannot rank his own book. However,in this case,the contrib- ing authors have high scientific standards and well-known achievements which speak for themselves. Transmembrane signaling has many different forms and biochemical and biophysical details. However,the final outcome of transmembrane signaling at the cellular level elucidates some cellular functions, which are at the center of se- defense, alimentation, escape reactions, etc. Transmembrane signaling can be studied best in the immune system,in particular in lymphocytes,the main cel- lar carriers of immune defense.
The different chapters are independent studies, written by well-known experts in their particular fields. Some chapters include the authors' very recent data, generalized, on the one hand, to provide und- standable material for those who are interested in the field but not experts. On the other hand,the current data and novel efforts to unify biochemical and bioph- ical events in a physiological description provide interesting reading for experts as well.

Contents:

The Impact of Environmental Signals on the Growth and Survival of Human T Cells.- Novel Single Cell Fluorescence Approaches in the Investigation of Signaling at the Cellular Level.- Non-Random Patterns of Membrane Proteins and Their Roles in Transmembrane Signaling.- Transmembrane Signals Mediated by IL-2 and IL-15 Control the Life and Death of Lymphocytes.- Single-Molecule Imaging of Diffusion, Recruitment, and Activation of Signaling Molecules in Living Cells.- Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations.- Signaling and Reverse Signaling in the Tumor Necrosis Factor/TNF Receptor System.- Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fc? Receptor.- Histamine Receptors and Signaling.- Signal Transduction by Ion Channels in Lymphocytes.