Main description:

The tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening.
Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.

Contents:

Tissue Engineering Models for Cancer Pathology;Introduction to the Tumor Microenvironment;Mimicking Fibrous Topographical Features of the Tumor Microenvironment;Mimicking Mechanical Features of the Tumor Microenvironment;Mimicking Chemical Features of the Tumor Microenvironment;Mimicking Multicellular Features of the Tumour Microenvironment;Cell Patterning to Mimic Tumor Anatomy;Advanced Scaffold Design via Electrospinning;Advanced Scaffold Fabrication using Additive Manufacturing;Microfluidic Models of the Tumour Microenvironment;Modeling of the Tumor Microenvironment in Tumor Organoids;Imaging in Scaffolds;The Intersection of Biomaterials,Tissue Engineering and Immuno-oncology;Tissue Engineered Models of Metastasis: Focus on Bone Metastasis;Tissue-engineered Cancer Models in Drug Screening