Main description:

Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). The intent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system.
In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.

Contents:

A. INTRODUCTION

1. Paramjit S. Tappia, Sukhwinder K. Bhullar, Naranjan S. Dhalla

Title: Biochemistry of cardiovascular dysfunction in obesity

B. HYPERTENSION

1. Coen D.A. Stehouwer

Title: Vascular mechanisms linking RAAS components to obesity-associated hypertension

2. Bonita Falkner

Title: Mechanisms of obesity-induced hypertension in adolescents

3. Murray Esler

Title: Role of the sympathetic nervous system in obesity-induced hypertension

4. Eric J. Belin de Chantemele

Title: Sex differences in the mechanisms associated with obesity-induced hypertension

5. Kamal Rahmouni

Title: Leptin as a mediator of obesity-induced hypertension

6. Atilla Engin

Title: Endothelial dysfunction in obesity

7. Geoffrey A, Head

Title: Neurohormonal regulation of sympathoexcitation and hypertension in obesity

8. Antonina Orlando

Title: Role of obesity in hypertension in children

9. Sochung Chung,

Title: Small for gestational age and obesity associated co-morbidities

10. Tammy M. Brady

Title: Obesity-Related Hypertension in Children

11. Massimo Leggio

Title: The relationship between obesity and hypertension

12. Jordana B. Cohen

Title: Hypertension in Obesity and the Impact of Weight Loss

13. Louis J. Aronne

Title: Parallels in the Evolution of Obesity and Hypertension

14. Gino Seravalle

Title: Obesity and hypertension

15. Daphne Merkus

Title: The microcirculation: a key player in obesity-associated cardiovascular disease

16. Eric J. Belin de Chantemele

Title: Sex Differences in Leptin Control of Cardiovascular Function in Health and Metabolic Diseases

17. Jun Wang

Title: Sex differences in the role of leptin and coronary heart disease

18. Susan Sam

Title: Differential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk

19. John Stafford

Title: Sex differences in lipid and lipoprotein metabolism

20. Hiroyuki Kobori

Title: Sex differences in the mechanisms of obesity-induced hypertension

C. HEART FAILURE

1. Jennifer E. Ho

Title: Impaired cardiac function in obese individuals

2. Devendra K. Agrawal

Title: Role of Vitamin D deficiency in cardiac function

3. Amanda R. Vest

Title: Obesity in advanced heart failure

4. Mahmoud Abdelaal

Title: Cardiovascular morbidity and mortality associated with obesity

5. Chayakrit Krittanawong

Title: Risk of overweight with the development of heart failure

6. Paul Mather

Title: Obesity and heart failure

7. Fabrizio Montecucco

Title: Obesity phenotypes and their paradoxical association with cardiovascular diseases

8. Raffaele Altara

Title: Mechanisms of heart failure with preserved ejection fraction in obesity

10. Sergey Kachur

Title: Obesity and cardiovascular diseases

11. Salvatore Carbone

Title: Obesity and Heart Failure: Possible mechanisms of the Obesity Paradox

12. Vijaiganesh Nagarajan

Title: Prognosis of morbid obesity patients with advanced heart failure

13. Carlos A. Aguilar-Salinas

Title: BMI as a risk factor for cardiovascular disease

14. Deepak L. Bhatt

Title: Relationship between BMI and cardiovascular outcomes in diabetic patients

15. Sheela N. Magge

Title: Cardiometabolic risk in obese children

16. Joran Hjelmeseth

Title: Gender related differences in obesity associated cardiovascular complications

17. Parham Parto

Title: Understanding the mechanisms and clinical significance of the obesity paradox

18. Altan Onat

Title: Advances in understanding gender difference in cardiometabolic disease risk

19. Naval K. Vikram

Title: Cardiovascular and Metabolic Complications - Diagnosis and Management in Obese Children

20. Martin A. Alpert

Title: Obesity and Ventricular Repolarization