Main description:

The new edition of a bestseller, this book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. The book places special emphasis on the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, drug metabolism and elimination, and the genetic basis for variations in drug response. The book includes revision and updates of chapters. It also includes new material on pharmacogenomics, cancer chemotherapies, and drug-receptor and drug-enzyme interactions.

Contents:

Preface. The Authors. Physicochemical Properties of Drugs. Fundamental Chemical Properties of Drugs. Acid-Base Properties of Drugs. Structural Determinants of Drug Action. Chemical Approaches to the Treatment of Cancer. Principles of Biopharmaceutics. Drug Administration and Absorption. Drug Distribution and Elimination. Metabolic Changes of Drugs. Principles of Drug-Receptor and Drug-Enzyme Interactions. Drug Receptors and Pharmacodynamics. Drug Induced Enzyme Inhibitions. Dopaminergic and Anti-Histamine Systems. Drug-Receptor Dynamics and Theories. Receptor Regulation and Signaling Mechanisms. Principles of Pharmacogenomics. Genetic Basis for Variations in Drug Response. Targeted Cancer Therapies. About the Author.