Main description:

Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin).
Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Contents:

1. Perspectives on tight junction research Jorg-Dieter Schulzke, Dorothee Gunzel, Lena J. John, and Michael Fromm Molecular properties of the tight junction 20. Charge-selective claudin channel Susanne M. Krug, Dorothee Gunzel, Marcel P. Conrad, In-Fah M. Lee, Salah Amasheh, Michael Fromm, and Alan S. L. Yu 29. Claudin-derived peptides are internalized via specific endocytosis pathways Denise Zwanziger, Christian Staat, Anuska V. Andjelkovic, and Ingolf E. Blasig 38. A phosphorylation hotspot within the occluding C-terminal domain Max J. Dorfel and Otmar Huber 45. Determinants contributing to claudin ion channel formation Anna Veshnyakova, Susanne M. Krug, Sebastian L. Mueller, Jorg Piontek, Jonas Protze, Michael Fromm, and Gerd Krause 54. Lipolysis-stimulted lipoprotein receptor: a novel membrane protein of tricellular tight junctions Mikio Furuse, Yukako Oda, Tomohito-Higashi, Noriko Iwamoto, and Sayuri Masuda 59. Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies Jan Rossa, Dorothea Lorenz, Martina Ringling, Anna Veshnyakova, and Joerg Piontek 67. Association between segments of zonula occludens proteins: live-cell FRET and mass spectrometric analysis Christine Rueckert, Victor Castro, Corinna Gagell, Sebastian Dabrowski, Michael Schumann, Eberhard Krause, Ingolf E. Blasig, and Reiner F. Haseloff 77. Dynamic properties of the tight junction barrier Christopher R. Weber Regulation of the tight junction and barrier function 85. Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells Takashi Kojima and Norimasa Sawada 93. The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation Michael Scharl and Gerhard Rogler 103. Caveolin binds independently to claudin-2 and occluding Christina M. Van Itallie and James M. Anderson 108. Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2 Declan F. McCole 115. Intracellular mediators of JAM-A-dependent epithelial barrier function Ana C. Monteiro and Charles A. Parkos 125. Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex Sandra Citi, Pamela Pulimeno, and Serge Paschoud 133. ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis Lorenza Gonzalez-Mariscal, Pablo Bautista, Susana Lechuga, and Miguel Quiros 142. From TER to trans- and paracellular resistance: lessons from impedance spectroscopy Dorothee Gunzel, Silke S. Zakrzewski, Thomas Schmid, Maria Pangalos, John Wiedenhoeft, Corinna Blasse, Christopher Ozboda, and Susanne M. Krug Tight junctions in skin, lung, endothelia, and nervous tissues 152. Diverse type of junctions containing tight junction proteins in stratified mammalian epithelia Werner W. Franke and Ulrich-Frank Pape 158. Barriers and more: functions of tight junction proteins in the skin Nina Kirschner and Johanna M. Brandner 167. Roles for claudins in alveolar epithelial barrier function Christian E. Overgaard, Leslie A. Mitchell, and Michael Koval 175. Claudins and alveolar epithelial barrier function in the lung James A. Frank 184. Relevance of endothelial junctions in leukocyte extravasation and vascular permeability Dietmar Vestweber 193. Involvement of claudins in zebrafish brain ventricle morphogenesis Jingjing Zhang, Martin Liss, Hartwig Wolburg, Ingolf E. Blasig, and Salim Abdelilah-Seyfried 199. Modulation of tight junction proteins in the perineurium for regional pain control D. Hackel, A. Brack, M. Fromm, and K. L. Rittner