Main description:

Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.

Contents:

The Puromycin-Sensitive Aminopeptidase: Role in Neurological, Reproductive, Immunological and Proliferative Disorders; M.W. Thompson, L.B. Hersh. Methionine Aminopeptidase: Emerging Role in Angiogenesis; J.A. Vetro, B. Dummitt, Yie-Hwa Chang. Placental Leucine Aminopeptidase; S. Nomura, T. Ito, S. Mizutani. Insulin-Regulated Aminopeptidase; Siew Yeen Chai, R. Fernando, Siying Ye, G.R. Peck, A.L. Albiston. Leukotriene A4 hydrolase: Molecular Properties and Involvement in Inflammation; F. Tholander, A. Wetterholm, J.Z. Haeggstroem. Arginyl Aminopeptidase; S. Cadel, C. Piesse, C. Gouzy-Darmon, P. Cohen, T. Foulon. TRH-Degrading Aminopeptidase: A regulator and terminator of TRH action? K. Bauer. ERAP1 and MHC Class I Antigen Presentation; T. Saric, A.L. Goldberg. CD13/Aminopeptidase N in Tumor Growth and Angiogenesis; N. Petrovic, W. Schacke, L.H. Shapiro. Alanyl-Aminopeptidases in Human T cells: Structures and functions; U. Lendeckel, A. Bukowska, J.H. Lattig, W. Brandt. Aminopeptidase Inhibitors as Anti-Hypertensive Drugs; X. Iturrioz, A. Reaux-Le Goazigo, C. Llorens-Cortes. Aminopeptidase P and Vasoactive Peptides: From fundamental aspects to clinical interests; G. Molinaro, G. Boileau, A. Adam. Nematode aminopeptidases; D.R. Brooks, R.E. Isaac.