Main description:

This volume contains the papers presented in the NATO Advanced Research Workshop "Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences" held in Nafplion, Greece on September 25-30, 1988. The objective of NATO ARW is to assess the state of-the-art in a given scientific area and to formulate recommendations for future research in emerging areas of science by promoting international scientific contacts. In the Nafplion meeting this objective was reached by an international group of speakers, senior Greek scientists and graduates involved in relevant research areas. The Workshop was made possible by the generous support of the Scientific Council of NATO. We thank Drs. G. Sinclair and L.V. daCunha, Directors of the NATO ARW's and ASI's (Advanced Study Institutes) respectively, for their wholehearted support and advice. The International Union of Biochemistry awarded additional travel grants leading to increased international participation. Furthermore, the Secretariat of Science and Technology, the Ministry of Culture and Sciences and the National Hellenic Research Foundation contributed financially and by supporting personnel. We sincerely thank all these organizations for their support. Our heartful thanks are also extended to the Mayor of the Municipality of Nafplion, Mr.

Contents:

Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences: A record of the Meeting.- Signal Transduction and Control of Cell Proliferation and Differentiation.- Insulin Receptor and Insulin Action.- Signal Transduction by Growth Factor Receptors.- Cholera Toxin: Transport and Structural Basis of Action.- Analysis and Transfection of Human Acidic Fibroblast Growth Factor (aFGF) cDNA Clones and Structural Analysis of the Human aFGF Gene reveals Features Shared within a Family of Homologous Proteins.- Growth Factor Synthesis by a Human Teratocarcinoma cell line: Implications for Autocrine Growth in the Human Embryo?.- The Role of Oncogene Activation.- The Role of Ras P21 Product in Cell Transformation.- DNA Binding Properties of the Thyroid Hormone Receptor/c-erbA Protein and its Viral Homologue P75 gag-v-erbA.- The Role of Fos in Gene Regulation.- 6-Phosphofructo-2-Kinase links Glycolysis to Mitogenic Agents and has Sequence Similarity with Proteins encoded by Oncogenic DNA Viruses.- Steroid Receptors and Transcriptional Control.- The Regulation of RNA Polymerase II Activity by Multisite Phosphorylation.- Transcription Factors of RNA Polymerase III from Mammalian Cells.- Steroid response elements: Composite Structure and Definition of a Minimal Element.- Gene Regulation by Steroid Hormones.- Regulation of Liver Gene Expression in Dexamethasone Resistant Hepatoma Cells.- The Kinetics of Oestrogen-induced Gene Expression in the Immature Rat Uterus.- Structure and Function of Steroid Receptors.- Functional Domains of Steroid Hormone Receptors.- Genetic and Biochemical Analysis of a Steroid Receptor.- Analysis of Subunit Interactions in Steroid Receptors using Chemical Cross-Linking.- Possible Functional Interaction between Steroid Hormone Receptors and Heat Shock Protein Mr 90.000 (hsp 90).- Mechanism of Action of Estrogens: Phosphorylation of Estradiol Receptor on Tyrosine.- Glucocorticoid Receptor and Hormonal Extragenomic Effects.- Clinical Implications of Steroid Receptor Research.- Estrogen Receptors in Mouse Mammary Tumors.- Structure of Glucocorticoid Receptor in Cancer Tissues.