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5-HT2A Receptors in the Central Nervous System

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MORE ABOUT THIS BOOK

Main description:

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets.


Contents:

Pharmacological analysis in favour of a physiological role for the constitutive activity of 5-HT2A receptors in learning.- Arrestins: Ligand-directed regulators of 5-HT2A receptor trafficking and signaling events.- 5-HT2A receptor heterodimerization Brain distribution.- PET imaging of the 5-HT2A receptor system: A tool to study the receptor's in vivo brain function.- Serotonergic receptor 5-HT2A in the cardiosympathovagal system.- Crosstalk between 5-HT2A and mGlu2 receptors: Implications in schizophrenia and its treatment.- Schizophrenia.- Role of Serotonin-2A Receptors in Pathophysiology and Treatment of Depression.- Brain circuits regulated by the 5-HT2A receptor: behavioural consequences on anxiety and fear memory.- 5-HT2A/2B/2C Receptors, Memory and Therapeutic Targets.- 5-HT2A receptors in the basal ganglia.- The involvement of 5-HT2A receptor in the regulation of sleep and wakefulness, and the potential therapeutic use of selective 5-HT2A receptor antagonists and inverse agonists for the treatment of an insomnia disorder.- 5-HT2A receptors and Pain.- 5-HT2A receptors in eating disorders.- Role of Serotonin2A (5-HT2A) Receptors in Epilepsy.- 5-HT2A receptors and BDNF regulation: Implications for Psychopathology.


PRODUCT DETAILS

ISBN-13: 9783319889450
Publisher: Springer (Birkhauser Verlag AG)
Publication date: June, 2019
Pages: 446
Weight: 700g
Availability: Contact supplier
Subcategories: Neuroscience

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