Main description:

A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.

Contents:

Part I: Basic Pathophysiology and Biochemistry of Diabetic Nephropathy

A. Pathophysiology

Angiotensin II and Its Receptors in the Pathogenesis of Diabetic Nephropathy
David J. Leehey, Ashok K. Singh, and Rekha Singh

Altered Renal Microvascular Function in Early Diabetes
Pamela K. Carmines, Joseph P. Bast, and Naohito Ishii

B. Interstitial Disease

Proteinuria and Interstitial Fibrogenesis in Diabetic Nephropathy
Raimund Hirschberg

C. Podocytes

Podocytes and Diabetic Nephropathy
George Jerums, Sianna Panagiotopoulos, and Richard MacIsaac

D. Altered Metabolic Pathways

Altered Glucose Transport and Its Metabolic Effects in Glomerular Cells
Charles W. Heilig

mRNA Translation in Diabetic Nephropathy
Balakuntalam S. Kasinath, Myung Ja Lee, Denis Feliers, and Nahum Sonenberg

The Hexosamine Biosynthesis Pathway: Contribution to the Pathogenesis of Diabetic Nephropathy
I. George Fantus, Howard J. Goldberg, Catharine I. Whiteside, and Delilah Topic

E. Nonenzymatic Glycosylation

Glycation: Receptor for Advanced Glycation Endproducts and Diabetic Nephropathy
Vivette D'Agati and Ann Marie Schmidt

F. Oxidative Stress

Oxidative and Glycooxidative Stress in Diabetic Nephropathy
Frederick R. DeRubertis and Patricia A. Craven

G. Growth Factors

Connective Tissue Growth Factor in the Pathogenesis of Diabetic Nephropathy: A Target for Therapeutic Intervention
Bruce L. Riser, Alessia Fornoni, and Sujatha Karoor

Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy
Geoffrey Boner and Mark E. Cooper

Transforming Growth Factor-b Signal Transduction in the Pathogenesis of Diabetic Nephropathy: Identifying Molecular Targets for Therapeutic Intervention
Sheldon Chen and Fuad N. Ziyadeh

H. New Approaches to the Study of Diabetic Nephropathy

Hepatocyte Growth Factor: Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathy
Shinya Mizuno and Toshikazu Nakamura

Proteomics in the Investigation of Diabetic Nephropathy
Visith Thongboonkerd

Gene Expression Profiling in the Investigation of Diabetic Nephropathy
Katalin Susztak, Erwin Bottinger, and Kumar Sharma

PPAR-g Ligands and Diabetic Nephropathy
Keiji Isshiki, Daisuke Koya, and Masakazu Haneda

a-Endosulfine in Diabetic Nephropathy
Jerry Yee and Balazs Szamosfalvi

The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathy
Keith A. Hruska, Laura DePetris, Tingting Li, Song Wang, Theresa Geurs, Frank Strebeck, Qing Chen, and Helen Liapis

Part II: Clinical Aspects of Diabetic Nephropathy

A. Genetics and Risks

Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes
Grzegorz Placha and Andrzej S. Krolewski

Major Risk Indicators for Diabetic Kidney Disease
Katherine R. Tuttle

B. Histopathology and Special Populations

The Structure of Human Diabetic Nephropathy
Michael Mauer and Behzad Najafian

Diabetic Kidney Disease in Transitional and Disadvantaged Populations
E. Jennifer Weil and Robert G. Nelson

C. Diagnosis and Treatment

Screening and Treatment of Early Diabetic Renal Disease in Type 1 and Type 2 Diabetes
Ellie Chuang and Mark E. Molitch

Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetes
Eberhard Ritz and Gunter Wolf

Diabetic and Renal Disease: ACE Inhibitors and/or Angiotensin Receptor Blockers: Does It Matter?
Carl Erik Mogensen and Niels Holmark Andersen

Management of Diabetic End-Stage Renal Disease With Dialysis
Ploumis S. Passadakis and Dimitrios G. Oreopoulos

D. Rela