Main description:

This Annals volume includes invited short reviews on topics presented at the 7th International Cancer Vaccine Symposium Renaissance of Cancer Immunotherapy , held September 9-11, 2012 in Florence, Italy. The papers cover the latest progress in basic immunology research and its translation to cancer patients. The meeting and papers pay tribute to the successes in the last few years that have led to the approval of new immunotherapies and the awarding of the Nobel Prize in medicine to three immunologists. The symposium is dedicated to one of these recipients, Dr. Ralph Steinman who discovered dendritic cells, immune cells that are vital in immune responses and immunotherapies for cancer. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.
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Contents:

Introduction to The Renaissance of Cancer Immunotherapy v Olivera J. Finn and Gerold Schuler Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy 1 Matthews D. Vesely and Robert D. Schreiber Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells 6 Maurizio Zanetti Immunotherapy in preneoplastic disease: targeting early procarcinogenic inflammatory changes that lead to immune suppression and tumor tolerance 12 Bridget Keenan and Elizabeth M. Jaffee Integration of epidemiology, immunobiology, and translational research for brain tumors 17 Hideho Okada, Michael E. Scheurer, Saumendra N. Sarkar, and Melissa L. Bondy Human dendritic cells subsets as targets and vectors for therapy 24 Eynav Klechevsky and Jacques Banchereau Dendritic cell immunotherapy 31 Rachel Lubong Sabado and Nina Bhardwaj Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance 46 Dylan J. Johnson and Pamela S. Ohashi Preventing cancer by targeting abnormally expressed self-antigens: MUC1 vaccines for prevention of epithelial adenocarcinomas 52 Pamela L. Beatty and Olivera J. Finn Immunological control of cell cycle aberrations for avoidance of oncogenesis: the case of tetraploidy 57 Laura Senovilla, Lorenzo Galluzzi, Maria Castedo, and Guido Kroemer Ongoing adaptive immune responses in the microenvironment of melanoma metastases 62 Nicolas van Baren and Pierre G. Coulie Main features of human T helper 17 cells 66 Francesco Annunziato, Lorenzo Cosmi, Francesco Liotta, Enrico Maggi, and Sergio Romagnani In silico modeling of cancel cell dissemination and metastasis 71 Lu-En Wai, Vipin Narang, Alexandre Gouaillard, Lai Guan Ng, and Jean-Pierre Abastado Common pathways to tumor rejection 75 Ena Wang, Davide Bedognetti, Sara Tomei, and Francesco M. Marincola Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy 80 Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto. Tomoko Iwata-Kajihara, Shoko Nakamura, Hiroshi Nishio, Ryosuke Satomi, Asuka Kobayashi, Mayuri Tanaka, Jeong Hoon Park, Hajime Kamijuku, Takahiro Tsujikawa, and Naoshi Kawamura