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Main description:
A NATO Advanced Study Institute on "Membrane Receptors, Dynamics and Energetics" was held in order to consider recent developments in membrane receptor research. Presentations and discussions focussed on signal transduction mechanisms (e.g. 2 G-proteins, transducin, Ca +) and on the structure and func- tion of some selected receptors (i.e. low density lipoprotein receptor, acetylcholine receptor, growth factor receptors, toxin receptors). These topics were put in the larger con- text of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth discussions of energy transduc- tion and transport mechanisms. Specialized membrane systems were discussed including chloroplasts and chromaffin granules. Functional relationships with specific lipids (e.g. phospho- inositides, lipid A) were major topics of discussion. This book presents the content of the major lectures and a selection of most relevant posters presented during the course of the Institute.
This book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics of re- ceptor, membrane and bioenergetics research that were at the center of interest during our stay on the Island of Spetsai from August 17 to 30, 1986.
Contents:
I. Signal Transduction Mechanisms.- The Amplifying Transduction Cascade Triggered by Rhodopsin in Visual Receptor Cells Biochemical and Biophysical Approaches.- Inositol Lipid Metabolism: Generation of Second Messengers.- Bradykinin-Induced Inositol Phosphate Metabolism in Human A431 Epidermoid Carcinoma Cells.- Mechanisms of Signal Transduction by Growth Factor Receptors.- Study of the Mechanism of Hormone Induced Desensitization and Internalization of Beta-Adrenergic Receptors.- Immunological Stimulation of Mast Cells Degranulation: Role of Cytosolic pH, Na+ and Ca2+ Ions.- II. Receptor Characteristics.- Nicotinic Acetylcholine Receptor and Myasthenia Gravis Studied by Anti-Receptor Monoclonal Antibodies.- Mutant Receptors for Low Density Lipoprotein in Familial Hypercholesterolemia.- Calcium and Guanosine Nucleotide Modulation of Melanotropin Receptor Function and Adenylate Cyclase in the M2R Melanoma Cell Line.- Structure-Function Studies of Growth-Factor Receptors.- Molecular Interactions of Ganglioside Receptors with Tetanotoxin on Solid Support, Aqueous Solutions and Natural Membranes.- Interaction of Cholera Toxin with its Receptor the Monosialoganglioside GM1: a Fluorescence Study.- Incorporation of GABA/Benzodiazepine Receptors into Natural Brain Lipid Liposomes: Biochemical Characterization.- Interaction of Laminin with Cell Membranes.- Solubilization of the Fusicoccin Receptor and a Protein Kinase from Highly Purified Plasma Membrane from Oat Roots.- III. Transport and Energetics.- Bacteriorhodopsin: Molecular Biology of the Light Activated Proton and Divalent Cation Receptor in the Membranes of Halobacteria.- Influence of the Chromophore Retinal and the State of Aggregation on the Proton/Hydroxyl Ion Flux across Bacteriorhodopsin.- Complete Tracking of Proton Flow in Thylakoids: the Unit Conductance of CFO is Greater than 10 fS.- Essential Role of Arginine Residues in the Interaction of F0 with F1 in Escherichia Coli ATP Synthase.- Solute Transport across Bacterial Membranes.- Regulation of Free Ca2+ in Resting and Con A-stimulated Mouse Splenocytes.- Possible Involvement of Phosphorylation/Dephosphorylation in the Regulation of Epithelial Sodium Channels.- Glycogen Metabolism in Smooth Muscle.- IV. Membranes and Lipids.- Dynamics of the Membranes of Chromaffin Granules.- The Role of Electrostatic Forces in Regulating Membrane Conformational Changes Induced by Protein Phosphorylation.- Oscillations in Wheat Chloroplast Photochemical Activity: Effect of Uncouplers.- Relationship of Cardiolipin to Cytochrome c Oxidase Kinetics as Probed by Adriamycin.- Molecular Dynamics and Selectivity in Biomembranes.- Structure and Function of Phosphoinositides in Membranes and Cells.- Time-Resolved Fluorescence Depolarization Studies on Parinaroyl Phosphatidylcholine in Triton X-100 Micelles and Rat Skeletal Muscle Membranes.- Genetic Basis of Membrane Phospholipid Diversity: a Summary.- Inositol Lipid Metabolism: a Topological Point of View.- Metabolism of Lyso(bis)phosphatidic Acid in Rabbit Alveolar Macrophages.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: December, 2012
Pages: 395
Weight: 773g
Availability: Available
Subcategories: Biochemistry
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