Main description:

Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area.
The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease.
Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets.
We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

Contents:

Part I Ion Channels in the Pulmonary Vasculature: Basics and New Findings

The Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction
E. Kenneth Weir, Jesus A. Cabrera, Saswati Mahapatra, Douglas A. Peterson, and Zhigang Hong

Two-Pore Domain K+ Channels and Their Role in Chemoreception
Keith J. Buckler

Intricate Interaction Between Store-Operated Calcium Entry and Calcium-Activated Chloride Channels
in Pulmonary Artery Smooth Muscle Cells
Abigail S. Forrest, Jeff E. Angermann, Rajesh Raghunathan, Catherine Lachendro, Iain A. Greenwood, and Normand Leblanc

The Role of Intracellular Ion Channels in Regulating Cytoplasmic Calciumin Pulmonary Arterial Mmooth Muscle: Which Store and Where?
A. Mark Evans

Ca2+ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle Cells
Michael J. Sanderson, Yan Bai, and Jose Perez-Zoghbi

Part II TRP Channels in the Pulmonary Vasculature:Basics and New Findings

Introduction to TRP Channels: Structure, Function, and Regulation
Michael Y. Song and Jason X.-J. Yuan
Physiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle Cells
Xiao-Ru Yang, Mo-Jun Lin, and James S. K. Sham

The Contribution of TRPC1 and STIM1 to Capacitative Ca2+ Entry in Pulmonary Artery
Lih Chyuan Ng, Judith A. Airey, and Joseph R. Hume

Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1
Donna L. Cioffi, Christina Barry, and Troy Stevens

TRPM2 Channel Regulates Endothelial Barrier Function
Claudie M. Hecquet, Gias U. Ahmmed, and Asrar B. Malik

Part III Pathogenic Role of Ion Channels in Pulmonary Vascular Disease

A Proposed Mitochondrial-Metabolic Mechanism for Initiation and Maintenance of Pulmonary Arterial Hypertension in Fawn-Hooded Rats: The Warburg Model of Pulmonary Arterial Hypertension
Jalees Rehman and Stephen L. Archer

The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary
Vasoconstriction
B.Fuchs, A. Dietrich, T. Gudermann, H. Kalwa, F. Grimminger, and N. Weissmann

Developmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary Vasculature
David N. Cornfield

Hypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth Muscle
Larissa A. Shimoda

CLC-3 Chloride Channels in the Pulmonary Vasculature
Joseph R. Hume, Ge-Xin Wang, Jun Yamazaki, Lih Chyuan Ng, and Dayue Duan

Part IV Receptors and Signaling Cascades in Pulmonary Arterial Hypertension

Role of Bone Morphogenetic Protein Receptors in the Development of Pulmonary Arterial Hypertension
Nicholas W. Morrell

Cross Talk Between Smad, MAPK, and Actin in the Etiology of Pulmonary Arterial Hypertension
James West

Notch Signaling in Pulmonary Hypertension
Patricia A. Thistlethwaite, Xiaodong Li, and Xiaoxue Zhang

Rho Kinase-Mediated Vasoconstriction in Pulmonary Hypertension
Ivan F. McMurtry, Kohtaro Abe, Hiroki Ota, Karen A. Fagan, and Masahiko Oka

The Serotonin Hypothesis of Pulmonary Hypertension Revisited
Margaret R. MacLean and Yvonne Dempsie

Impaired Vascular Endothelial Growth Factor Signaling in the Pathogenesis of Neonatal Pulmonary Vascular Disease
Steven H. Abman

Part V Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction

Mitochondrial Regulation of Oxygen Sensing
Navdeep S. Chandel

Reactive Oxygen Species and RhoA Signaling in Vascular Smooth Muscle: Role in Chronic Hypoxia-Induced
Pulmonary Hypertension
Thomas C. Resta, Brad R. S. Broughton, and Nikki L. Jernigan

Polyamine Regulatory Pathways as Pharmacologic Targets in Pulmonary Arterial Hypertension
Mark N. Gillespie, and Jack W. Olson

5-HT Receptors and KV Channel Internalization
Angel Cogolludo and Francisco Perez-Vizcaino
Part VI Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease

KCNQ Potassium Channels: New Targets for Pulmonary
Vasodilator Drugs? Alison M. Gurney, Shreena Joshi, and B